Bernard D Hummel

US Patent:

20050131028, Jun 16, 2005

Filed:

Sep 9, 2004

Appl. No.:

10/936875

Inventors:

Jeffery Carter - Chesterfield MO, US
Bernard Hummel - Kalamazoo MI, US

Assignee:

Pharmacia Corporation - Chesterfield MO

International Classification:

A61K031/4439
A61K031/44
A61K031/4152
A61K031/365

US Classification:

514341000, 514357000, 514406000, 514471000

Abstract:

A method is disclosed for providing extended duration treatment or prevention of pain, inflammation and inflammation-related disorders in a subject in need of such extended duration treatment or prevention by administering to the subject a Cox-2 selective inhibitor having certain added substituent groups. Also disclosed is a method for extending the duration of the plasma half-life of diaryl-substituted Cox-2 selective inhibitors by substituting halogen, haloalkyl, haloalkoxy, alkyl, nitrile, cyano or alkoxy groups at certain positions on the diaryl-substituted rings of the inhibitor molecule. A novel composition comprising such extended duration Cox-2 selective inhibitors is also disclosed.