Behjatolah Karbassi - Little Rock AR, US Thomas Kieber-Emmons - Little Rock AR, US
Assignee:
Board of Trustees of the University of Arkansas - Little Rock AR
International Classification:
A61K 39/395 A61K 38/47 A61K 31/737
US Classification:
424146100, 424094610, 514054000, 424178100
Abstract:
P-Selectin on platelets and endothelium binds cell surface chondroitin sulfate (CS) proteoglycans, which are abundantly and stably expressed on the surface many cancer cells. Binding of the cancer cells through the CS moieties may be blocked to inhibit the interaction of cancer cells with platelets and endothelium. The present inventors disclose compositions and methods for the inhibition of cancer metastasis.
P-Selectin on platelets and endothelium binds cell surface chondroitin sulfate (CS) proteoglycans, which are abundantly and stably expressed on the surface many cancer cells. Binding of the cancer cells through the CS moieties may be blocked to inhibit the interaction of cancer cells with platelets and endothelium. The present inventors disclose compositions and methods for the inhibition of cancer metastasis.
Compositions For And Methods Of Treating And Preventing Cancer Targeting Tumor Associated Carbohydrate Antigens
Compositions useful to induce anti-TACA immune response and kits comprising the same and methods of using the compositions to treat and prevent cancer are disclosed. Isolated human antibodies which bind to a carbohydrate mimetic peptide and methods of making the same and using the same to treat and prevent cancer are disclosed. Isolated human NK cells useful to kill tumor cells, and isolated human dendritic cells, and methods of making the same and using the same to treat and prevent cancer are disclosed.
Compositions For And Methods Of Treating And Preventing Targeting Tumor Associated Carbohydrate Antigens
Compositions useful to induce anti-TACA immune response and kits comprising the same and methods of using the compositions to treat and prevent cancer are disclosed. Isolated human antibodies which bind to a carbohydrate mimetic peptide and methods of making the same and using the same to treat and prevent cancer are disclosed. Isolated human NK cells useful to kill tumor cells, and isolated human dendritic cells, and methods of making the same and using the same to treat and prevent cancer are disclosed.
Behjatolah M. Karbassi - Little Rock AR, US Thomas Kieber-Emmons - Little Rock AR, US
Assignee:
The Board of Trustees of the University of Arkansas - Little Rock AR
International Classification:
C07K 16/18 C07K 14/47
US Classification:
4241741, 4242771
Abstract:
P-Selectin on platelets and endothelium binds cell surface chondroitin sulfate (CS) proteoglycans, which are abundantly and stably expressed on the surface many cancer cells. Binding of the cancer cells through the CS moieties may be blocked to inhibit the interaction of cancer cells with platelets and endothelium. The present inventors disclose compositions and methods for the inhibition of cancer metastasis.
Resumes
Assistant Professor At University Of Arkansas For Medical Sciences