Behjatolah Monzavi Karbassi

US Patent:

20070231332, Oct 4, 2007

Filed:

Mar 30, 2007

Appl. No.:

11/694370

Inventors:

Behjatolah Karbassi - Little Rock AR, US
Thomas Kieber-Emmons - Little Rock AR, US

Assignee:

Board of Trustees of the University of Arkansas - Little Rock AR

International Classification:

A61K 39/395
A61K 38/47
A61K 31/737

US Classification:

424146100, 424094610, 514054000, 424178100

Abstract:

P-Selectin on platelets and endothelium binds cell surface chondroitin sulfate (CS) proteoglycans, which are abundantly and stably expressed on the surface many cancer cells. Binding of the cancer cells through the CS moieties may be blocked to inhibit the interaction of cancer cells with platelets and endothelium. The present inventors disclose compositions and methods for the inhibition of cancer metastasis.

US Patent:

20090136488, May 28, 2009

Filed:

Oct 4, 2008

Appl. No.:

12/286950

Inventors:

Behjatolah M. Karbassi - Little Rock AR, US
Thomas Kieber-Emmons - Little Rock AR, US

Assignee:

The Board of Trustees of the University of Arkansa - Little Rock AR

International Classification:

A61K 39/395
C12Q 1/48
A61K 35/12
A61K 38/00
G01N 33/53

US Classification:

4241301, 435 15, 435 71, 424 937, 4241841

Abstract:

P-Selectin on platelets and endothelium binds cell surface chondroitin sulfate (CS) proteoglycans, which are abundantly and stably expressed on the surface many cancer cells. Binding of the cancer cells through the CS moieties may be blocked to inhibit the interaction of cancer cells with platelets and endothelium. The present inventors disclose compositions and methods for the inhibition of cancer metastasis.

US Patent:

20190216907, Jul 18, 2019

Filed:

Mar 27, 2019

Appl. No.:

16/367213

Inventors:

- Little Rock AR, US
Anastas Pashov - Sofia, BG
Behjatolah Karbassi - Little Rock AR, US

International Classification:

A61K 39/00
A61K 31/704
A61K 35/15
A61K 35/17
C07K 16/32
C07K 7/08
A61K 31/7024
A61K 31/138
A61K 31/337
A61K 31/475
A61K 31/675
A61K 45/06
C12N 5/09
C07K 14/47
C07K 16/18
C12N 5/0783
A61K 39/39

Abstract:

Compositions useful to induce anti-TACA immune response and kits comprising the same and methods of using the compositions to treat and prevent cancer are disclosed. Isolated human antibodies which bind to a carbohydrate mimetic peptide and methods of making the same and using the same to treat and prevent cancer are disclosed. Isolated human NK cells useful to kill tumor cells, and isolated human dendritic cells, and methods of making the same and using the same to treat and prevent cancer are disclosed.

US Patent:

20160184415, Jun 30, 2016

Filed:

Jul 31, 2014

Appl. No.:

14/908503

Inventors:

- Little Rock AR, US
Anastas Pashov - Little Rock AR, US
Behjatolah Karbassi - Little Rock AR, US

International Classification:

A61K 39/00
C07K 7/08
A61K 45/06
C12N 5/0783
C07K 16/18
A61K 39/39
C12N 5/09
A61K 35/17
A61K 35/15

Abstract:

Compositions useful to induce anti-TACA immune response and kits comprising the same and methods of using the compositions to treat and prevent cancer are disclosed. Isolated human antibodies which bind to a carbohydrate mimetic peptide and methods of making the same and using the same to treat and prevent cancer are disclosed. Isolated human NK cells useful to kill tumor cells, and isolated human dendritic cells, and methods of making the same and using the same to treat and prevent cancer are disclosed.

US Patent:

20140248290, Sep 4, 2014

Filed:

Apr 5, 2012

Appl. No.:

13/440137

Inventors:

Behjatolah M. Karbassi - Little Rock AR, US
Thomas Kieber-Emmons - Little Rock AR, US

Assignee:

The Board of Trustees of the University of Arkansas - Little Rock AR

International Classification:

C07K 16/18
C07K 14/47

US Classification:

4241741, 4242771

Abstract:

P-Selectin on platelets and endothelium binds cell surface chondroitin sulfate (CS) proteoglycans, which are abundantly and stably expressed on the surface many cancer cells. Binding of the cancer cells through the CS moieties may be blocked to inhibit the interaction of cancer cells with platelets and endothelium. The present inventors disclose compositions and methods for the inhibition of cancer metastasis.