Arutselvan Natarajan from Sunnyvale, CA

Site-Specific Conjugation Of Ligands To Nanoparticles
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US Patent:

20100179303, Jul 15, 2010
Filed:

Apr 25, 2008
Appl. No.:

12/597866
Inventors:

Arutselvan Natarajan - Sacramento CA, US
Sally J. Denardo - El Macero CA, US
Gerald L. Denardo - El Macero CA, US
Cordula Gruettner - Rostock-Warnemuende, DE
Assignee:

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA - OAKLAND CA
International Classification:

C07K 14/00
C07K 2/00
C07K 16/00
US Classification:

530300, 530402, 5303911, 5303915, 977773
Abstract:

A new radioconjugate NP has been developed using recombinant antibody fragments, di-scFv-c (111 In-DOTA-di-scFv-NP) for imaging and therapy of anti MUC-1 10 expressing cancers since aberrant MUC-1 Is abundantly expressed on the majority of human epithelial cancers. Selection and engineering of anti-MUC-1 di-scFv-c (50 kDa) was generated to link NP-M (maleimide). DOTA chelate was conjugated with di-scFv-c for the radiometal chelation to trace the RINP at in vivo. This RINP preparation can provide uniquely high tumor cell binding NP for AMF driven tumor hyperthermia.

Construction Of A Multivalent Scfv Through Alkyne-Azide 1,3-Dipolar Cycloaddition
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US Patent:

20090234105, Sep 17, 2009
Filed:

Mar 26, 2007
Appl. No.:

12/294227
Inventors:

Jacquelyn Gervay-Hague - Davis CA, US
Wenjun Du - St. Louis MO, US
Sally Denardo - El Macero CA, US
Arutselvan Natarajan - Sacramento CA, US
Assignee:

The Regents of the University of California - Oakland CA
International Classification:

C07K 16/46
A61P 35/00
US Classification:

5303873
Abstract:

The present invention provides for a practical, universal and efficient method to ligate two large macromolecules (e.g., proteins) using the alkyne-azide 1,3-dipolar cycloaddition reaction to produce a conjugated macromolecule, such as a multivalent scFv. The present invention also provides for conjugate macromolecules comprising a plurality of macromolecule components cross-linked through at least one linking group comprising at least one 1,2,3-triazole moiety, wherein at least 50 percent of the macromolecule components in the conjugate macromolecule has only one site available for cross-linking.

Probes And Methods Of Imaging Non-Hodgkins Lymphoma
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US Patent:

20140271467, Sep 18, 2014
Filed:

Mar 11, 2014
Appl. No.:

14/204039
Inventors:

- Palo Alto CA, US
Arutselvan Natarajan - Sunnyvale CA, US
Sanjiv S. Gambhir - Portola Valley CA, US
International Classification:

A61K 51/08
US Classification:

424 169, 435 723, 530400
Abstract:

Embodiments of the present disclosure provide for labeled probes such as a Cu-FN3 probe (FN3 refers to fibronectin type 3 domain); methods of making labeled probes; pharmaceutical compositions including labeled probes; methods of using labeled probes; methods of diagnosing, localizing, monitoring, and/or assessing non-Hodgkin's lymphoma, cancers, tumors, precancerous cells, and related biological events using labeled probes; kits for diagnosing, localizing, monitoring, and/or assessing non-Hodgkin's lymphoma, cancers, tumors, precancerous cells, and related biological events; and the like.

Methods Of Treating Cancer Sensitive To Anti-Egfr Therapy And Modifying Treatment Using Blood Biomarkers
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US Patent:

20140275073, Sep 18, 2014
Filed:

Mar 12, 2014
Appl. No.:

14/206223
Inventors:

- Palo Alto CA, US
Lingyun Xu - Fremont CA, US
Nick Hughes - Orinda CA, US
Carsten H. Nielsen - Copenhagen N, DK
Sanjiv S. Gambhir - Portola Valley CA, US
Parag Mallick - San Mateo CA, US
Arutselvan Natarajan - Sunnyvale CA, US
International Classification:

G01N 33/574
A61K 31/517
A61K 31/5377
US Classification:

5142345, 435 74, 435 613, 5142664
Abstract:

The present disclosure provides methods of treating cancer and modifying a cancer treatment for a cancer with an anti-EGFR drug by creating PRDX6 expression profiles and using the profiles to evaluate and optionally modify treatment. The present disclosure also provides assays and systems for assessing sensitivity of a cancer to an anti-EGFR therapy.

Immuno Imaging Agent For Use With Antibody-Drug Conjugate Therapy
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US Patent:

20140255305, Sep 11, 2014
Filed:

Feb 5, 2014
Appl. No.:

14/173638
Inventors:

- Palo Alto CA, US
- Paris, FR
Susanta K. Sarkar - Cambridge MA, US
Mathias Gebauer - Frankfurt, DE
Christian Lange - Frankfurt, DE
Ingo Focken - Hocheim, DE
Richard Kimura - Stanford CA, US
Arutselvan Natarajan - Sunnyvale CA, US
Ohad Ilovich - Sunnyvale CA, US
International Classification:

A61K 51/10
C07K 16/46
US Classification:

424 153, 5303873, 5303915, 5303919
Abstract:

The invention relates to a companion diagnostic antibody-like binding protein based on the humanized monoclonal antibody, DS6, to be used as diagnostic tool for in vivo detection and quantification of the tumor-associated MUC1-sialoglycotope, CA6.

Arutselvan Natarajan