Arun K Kashyap

US Patent:

8148085, Apr 3, 2012

Filed:

Sep 11, 2007

Appl. No.:

11/853795

Inventors:

Lawrence Horowitz - Atherton CA, US
Ramesh Bhatt - Belmont CA, US
Arun K. Kashyap - San Francisco CA, US

Assignee:

Sea Lane Biotechnologies, LLC - Atherton CA

International Classification:

G01N 33/53
C07H 21/04

US Classification:

435 71, 536 2353

Abstract:

The present invention concerns donor-specific antibody libraries derived from a patient donor who has suffered from, or is suffering from one or more diseases discussed herein. The present invention also concerns the method of making and using the donor-specific antibodies. The present invention further concerns the neutralizing antibodies obtained from the donor-specific antibody libraries and the methods of using these antibodies for the prevention/treatment of human disease.

US Patent:

20080014205, Jan 17, 2008

Filed:

May 15, 2007

Appl. No.:

11/748980

Inventors:

Lawrence Horowitz - Atherton CA, US
Ramesh Bhatt - Belmont CA, US
Arun Kashyap - Newark CA, US

International Classification:

A61K 39/395
C07K 16/08
C40B 30/04
C40B 40/10

US Classification:

424159100, 506018000, 506009000, 530387300, 530389400

Abstract:

The present invention concerns methods and means for identifying, producing, and engineering neutralizing antibodies against influenza A viruses, and to the neutralizing antibodies produced. In particular, the invention concerns neutralizing antibodies against various influenza A virus subtypes, including neutralizing antibodies against two or more of H1, H2, H3, H5, H7 and H9, such as, for example all of H1, H2, H3, and H5 subtypes, and methods and means for making such antibodies. More specifically, the invention concerns antibodies capable of neutralizing more than one, preferably all, isolates of an influenza A virus subtype.

US Patent:

20100040635, Feb 18, 2010

Filed:

Mar 27, 2009

Appl. No.:

12/413308

Inventors:

Lawrence Horowitz - Atherton CA, US
Ramesh Bhatt - Belmont CA, US
Arun Kashyap - Newark CA, US

Assignee:

Sea Lane Biotechnologies - Atherton CA

International Classification:

A61K 39/395
C07K 16/00
A61P 31/16
C12Q 1/70
C40B 40/10

US Classification:

4241591, 5303894, 5303891, 435 5, 506 18

Abstract:

The present invention concerns methods and means for identifying, producing, and engineering neutralizing molecules against influenza A viruses, and to the neutralizing molecules produced. In particular, the invention concerns neutralizing molecules against various influenza A virus subtypes, including neutralizing antibodies against H5 and/or H3 and/or H1, such as, for example all of H1, H3, and H5 subtypes, and methods and means for making such molecules.

US Patent:

20100291066, Nov 18, 2010

Filed:

Sep 11, 2008

Appl. No.:

12/676737

Inventors:

Lawrence Horowitz - Atherton CA, US
Ramesh Bhatt - Belmont CA, US
Arun K. Kashyap - Newark CA, US

International Classification:

C40B 40/10
C40B 40/08
C40B 40/02
C40B 50/00
A61K 39/395
A61P 31/16
G01N 33/68

US Classification:

4241301, 506 17, 506 14, 506 18, 506 23, 436 89

Abstract:

The present application concerns donor-specific antibody libraries derived from a patient donor who has suffered from, or is suffering from one or more diseases discussed herein. The present application also concerns the method of making and using the donor-specific antibodies. The present application further concerns the neutralizing antibodies obtained from the donor-specific antibody libraries and the methods of using these antibodies for the prevention/treatment of human disease.

US Patent:

20100316654, Dec 16, 2010

Filed:

Jul 12, 2010

Appl. No.:

12/834736

Inventors:

Lawrence Horowitz - Atherton CA, US
Ramesh Bhatt - Belmont CA, US
Arun K. Kashyap - Newark CA, US

International Classification:

A61K 39/42
C07K 16/08
A61P 31/16

US Classification:

4241591, 5303871

Abstract:

The present invention concerns methods and means for identifying, producing, and engineering neutralizing antibodies against influenza A viruses, and to the neutralizing antibodies produced. In particular, the invention concerns neutralizing antibodies against various influenza A virus subtypes, including neutralizing antibodies against two or more of H1, H2, H3, H5, H7 and H9, such as, for example all of H1, H2, H3, and H5 subtypes, and methods and means for making such antibodies. More specifically, the invention concerns antibodies capable of neutralizing more than one, preferably all, isolates of an influenza A virus subtype.

US Patent:

20120093834, Apr 19, 2012

Filed:

Jul 18, 2011

Appl. No.:

13/185386

Inventors:

Lawrence HOROWITZ - Atherton CA, US
Ramesh Bhatt - Belmont CA, US
Arun Kashyap - Newark CA, US

International Classification:

A61K 39/145
A61P 31/16
A61P 37/04
A61K 39/395

US Classification:

4241591, 4242101

Abstract:

The present invention concerns methods and means for identifying, producing, and engineering neutralizing molecules against influenza A viruses, and to the neutralizing molecules produced. In particular, the invention concerns neutralizing molecules against various influenza A virus subtypes, including neutralizing antibodies against H5 and/or H3 and/or H1, such as, for example all of H1, H3, and H5 subtypes, and methods and means for making such molecules.

US Patent:

20120107326, May 3, 2012

Filed:

Aug 10, 2011

Appl. No.:

13/207083

Inventors:

Lawrence HOROWITZ - Atherton CA, US
Ramesh Bhatt - Belmont CA, US
Arun K. Kashyap - Newark CA, US

International Classification:

A61K 39/42
A61P 31/16

US Classification:

4241591

Abstract:

The present invention concerns methods and means for identifying, producing, and engineering neutralizing antibodies against influenza A viruses, and to the neutralizing antibodies produced. In particular, the invention concerns neutralizing antibodies against various influenza A virus subtypes, including neutralizing antibodies against two or more of H1, H2, H3, H5, H7 and H9, such as, for example all of H1, H2, H3, and H5 subtypes, and methods and means for making such antibodies. More specifically, the invention concerns antibodies capable of neutralizing more than one, preferably all, isolates of an influenza A virus subtype.

US Patent:

20120128671, May 24, 2012

Filed:

May 12, 2010

Appl. No.:

13/261004

Inventors:

Lawrence Horowitz - Atherton CA, US
Ramesh Bhatt - Belmont CA, US
Arun Kashyap - Newark CA, US

International Classification:

A61K 39/42
C07K 19/00
A61P 37/04
A61K 39/145
A61P 31/16
C07K 16/00
C07K 16/10

US Classification:

4241341, 5303891, 5303873, 5303894, 4241591, 4242091

Abstract:

The present invention concerns methods and means for identifying, producing, and engineering neutralizing antibodies against influenza A viruses, and to the neutralizing antibodies produced. In particular, the invention concerns neutralizing antibodies against various influenza A virus subtypes, and methods and means for making such antibodies.