Anusha Rajan

US Patent:

20220401537, Dec 22, 2022

Filed:

Sep 15, 2020

Appl. No.:

17/760747

Inventors:

- Seattle WA, US
Stanley R. RIDDELL - Sammamish WA, US
Anusha RAJAN - Woodinville WA, US

International Classification:

A61K 39/00
C07K 14/71
C07K 14/725
C07K 14/705
C07K 14/73
C07K 16/28
A61P 35/00
C12N 15/62
C12N 15/86
C12N 5/0783

Abstract:

The present disclosure provides fusion proteins with improved signaling properties. Disclosed embodiments include fusion proteins that comprise an extracellular component comprising a target-binding domain, a transmembrane domain, and an intracellular component comprising a SH2 domain or a functional portion or variant thereof, and have improved signaling in response to antigen-binding, including of solid-tumor antigens with low levels of expression. Recombinant host cells expressing the fusion proteins, and polynucleotides encoding the fusion proteins, are also provided, as are compositions and methods comprising the same.