Anu Wallecha from 101 Wildflower Cir, Yardley, PA 19067, age 50, Phone: 215-369-3332

Multiple Delivery System For Heterologous Antigens
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US Patent:

20120135033, May 31, 2012
Filed:

Nov 7, 2011
Appl. No.:

13/290783
Inventors:

ANU WALLECHA - YARDLEY PA, US
International Classification:

A61K 39/00
C12N 15/74
C12N 1/21
C40B 40/06
C12N 15/12
A61P 35/00
US Classification:

4242001, 536 235, 4352523, 506 16, 435476
Abstract:

The invention is directed to an episomal recombinant nucleic acid encoding at least two heterologous antigens each fused to a PEST-endogenous polypeptide, vaccines comprising the same, methods of preparing same, and methods of inducing an immune response, and treating, inhibiting, or suppressing cancer or tumors comprising administering the same.

Dual Delivery System For Heterologous Antigens
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US Patent:

20110129499, Jun 2, 2011
Filed:

May 19, 2009
Appl. No.:

12/993380
Inventors:

Paulo Maciag - Robbinsville NJ, US
Anu Wallecha - Yardley PA, US
Vafa Shahabi - Valley Forge PA, US
International Classification:

A61K 39/02
C12N 1/21
A61K 35/12
C12N 15/74
A61P 35/00
A61P 31/04
A61P 37/04
US Classification:

4242341, 4352523, 424 932, 435471
Abstract:

Provided herein are recombinant strains expressing a tumor-specific antigenic polypeptide and, optionally, an angiogenic polypeptide wherein a nucleic acid molecule encoding at least one of the polypeptides is operably integrated into the genome in an open reading frame with a nucleic acid sequence encoding a PEST-containing polypeptide, methods of preparing same, and methods of inducing an immune response, and treating, inhibiting, or suppressing cancer or tumors comprising administering same.

Compositions And Methods For Evaluating Attenuation And Infectivity Of Listeria Strains
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US Patent:

20210003558, Jan 7, 2021
Filed:

Mar 8, 2019
Appl. No.:

16/979436
Inventors:

- Princeton NJ, US
Anu WALLECHA - Yardley PA, US
Assignee:

ADVAXIS, INC. - Princeton NJ
International Classification:

G01N 33/50
C12N 1/20
G01N 33/483
Abstract:

Methods and compositions are provided for assessing attenuation and/or infectivity of bacteria or strains, such as

Compositions And Methods For Lyophilization Of Bacteria Or Listeria Strains
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US Patent:

20200261369, Aug 20, 2020
Filed:

Aug 29, 2018
Appl. No.:

16/647977
Inventors:

- PRINCETON NJ, US
Anu WALLECHA - Yardley PA, US
Mike GRACE - Princeton NJ, US
Melissa GOSSE - Jackson NJ, US
Assignee:

ADVAXIS, INC. - PRINCETON NJ
International Classification:

A61K 9/19
C12N 1/20
A61K 35/74
Abstract:

Methods and compositions are provided for lyophilization of bacteria or strains, such as . Provided are methods for producing a lyophilized composition comprising a bacteria or strain, formulations for lyophilization comprising a bacteria or strain, lyophilized bacteria or strains, and methods of preparing frozen bacteria or strains for lyophilization.

Combination Of Listeria-Based Vaccine With Anti-Ox40 Or Anti-Gitr Antibodies
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US Patent:

20170368157, Dec 28, 2017
Filed:

Dec 18, 2015
Appl. No.:

15/533645
Inventors:

- Princeton NJ, US
- Augusta GA, US
Robert Petit - Newton PA, US
Anu Wallecha - Yardley PA, US
International Classification:

A61K 39/00
C07K 16/28
C07K 14/025
Abstract:

Disclosed herein are compositions comprising use of compositions comprising a live attenuated recombinant strain comprising a fusion protein of a truncated listeriolysin O (LLO) protein, a truncated ActA protein, or a PEST amino acid sequence fused to a heterologous antigen, including a tumor-associated antigen, wherein the compositions further comprise or are co-administered with an antibody or fragment thereof. Also disclosed are combination therapies comprising use of these compositions comprising live attenuated recombinant strains, in conjunction with an antibody or fragment thereof for use in treating, protecting against, and/or inducing an immune response against a tumor, especially wherein the treating, protection against and/or inducing an immune response increases percent survival in a subject.

Suppressor Cell Function Inhibition Following Listeria Vaccine Treatment
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US Patent:

20150098964, Apr 9, 2015
Filed:

Mar 12, 2013
Appl. No.:

14/383970
Inventors:

- Princeton NJ, US
Anu Wallecha - Yardley PA, US
International Classification:

A61K 39/02
A61K 35/74
US Classification:

4242001
Abstract:

This invention provides methods and compositions for using a live attenuated for inhibiting cell-mediated suppression of anti-disease infiltrating T lymphocytes in a subject having the disease.

Dual Delivery System For Heterologous Antigens
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US Patent:

20140335120, Nov 13, 2014
Filed:

Jul 25, 2014
Appl. No.:

14/341215
Inventors:

- Princeton NJ, US
Anu Wallecha - Yardley PA, US
Vafa Shahabi - Valley Forge PA, US
International Classification:

C12N 15/74
C07K 14/705
A61K 39/39
C07K 14/195
US Classification:

4241901, 4352523, 435471, 4242001
Abstract:

Provided herein are recombinant strains expressing a tumor-specific antigenic polypeptide and, optionally, an angiogenic polypeptide wherein a nucleic acid molecule encoding at least one of the polypeptides is operably integrated into the genome in an open reading frame with a nucleic acid sequence encoding a PEST-containing polypeptide, methods of preparing same, and methods of inducing an immune response, and treating, inhibiting, or suppressing cancer or tumors comprising administering same.

Dual Delivery System For Heterologous Antigens
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US Patent:

20140314708, Oct 23, 2014
Filed:

Mar 11, 2014
Appl. No.:

14/204806
Inventors:

- East Princeton NJ, US
Anu Wallecha - Yardley PA, US
Vafa Shahabi - Valley Forge PA, US
Assignee:

Advaxis, Inc. - East Princeton NJ
International Classification:

C12N 15/74
A61K 39/39
A61K 39/00
US Classification:

424 851, 4352523, 4242001
Abstract:

Provided herein are recombinant strains expressing a tumor-specific antigenic polypeptide and, optionally, an angiogenic polypeptide wherein a nucleic acid molecule encoding at least one of the polypeptides is operably integrated into the genome in an open reading frame with a nucleic acid sequence encoding a PEST-containing polypeptide, methods of preparing same, and methods of inducing an immune response, and treating, inhibiting, or suppressing cancer or tumors comprising administering same.

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Skills:

Medical Affairs
French

Anu Wallecha