Robert J. DeVita - Westfield NJ, US Greg J. Morriello - Randolph NJ, US Anthony K. Ogawa - Mountainside NJ, US Feroze Ujjainwalla - Scotch Plains NJ, US
Assignee:
Merck Sharp & Dohme Corp. - Rahway NJ
International Classification:
A61K 31/67 C07H 7/02 A61K 31/70 A61P 9/10
US Classification:
514 23, 536 53
Abstract:
This invention provides cholesterol absorption inhibitors of Formula (I), and the pharmaceutically acceptable salts and esters thereof. The compounds are useful for lowering plasma cholesterol levels, particularly LDL cholesterol, and for treating and preventing atherosclerosis and atherosclerotic disease events.
Lin Chu - Scotch Plains NJ, US Bing Li - Towaco NJ, US Anthony K. Ogawa - Mountainside NJ, US Hyun O. Ok - Colonia NJ, US Debra L. Ondeyka - Fanwood NJ, US Minal Patel - Galloway NJ, US Rosemary Sisco - Old Bridge NJ, US Feroze Ujjainwalla - Scotch Plains NJ, US Jinyou Xu - Scotch Plains NJ, US
Anthony Ogawa - Mountainside NJ, US Hyun O. Ok - Colonia NJ, US Debra Ondeyka - Fanwood NJ, US Feroze Ujjainwalla - Scotch Plains NJ, US Ellen Vande Bunte - Colts Neck NJ, US
This invention provides compounds of Formula (I) which are PAFR antagonists: Formula (I) and the pharmaceutically acceptable salts thereof. The compounds are useful for treating PAF-mediated disorders, and can be used in methods for treating atherosclerosis and preventing or reducing risk for atherosclerotic disease events. The compounds are also useful for treating or ameliorating pain, e. g. inflammatory pain and/or nociceptive pain, and for treating or ameliorating autoimmune and/or inflammatory diseases, among other conditions.
Lin Chu - Scotch Plains NJ, US Bing Li - Towaco NJ, US Anthony K. Ogawa - Mountainside NJ, US Hyun O. Ok - Colonia NJ, US Debra L. Ondeyka - Fanwood NJ, US Minal Patel - Galloway NJ, US Rosemary Sisco - Old Bridge NJ, US Feroze Ujjainwalla - Scotch Plains NJ, US Jinyou Xu - Scotch Plains NJ, US
Anthony Ogawa - Mountainside NJ, US Feroze Ujjainwalla - Scotch Plains NJ, US Ellen K. Vande Bunte - Colts Neck NJ, US Lin Chu - Scotch Plains NJ, US Debra Ondeyka - Fanwood NJ, US Ihor Kopka - Hampton NJ, US Bing Li - Towaco NJ, US Hyun Ok - Colonia NJ, US Minal J. Patel - East Orange NJ, US Jinyou Xu - Scotch Plains NJ, US Rosemary Sisco - Reading PA, US
The instant invention provides compounds of Formula I which are 5-lipoxygenase activating protein inhibitors. Compounds of Formula (I) are useful as anti-atherosclerotic, anti-asthmatic, anti-allergic, anti-inflammatory and cytoprotective agents.
This invention provides compounds of Formula I which are PAFR antagonists: I and the pharmaceutically acceptable salts thereof. The compounds are useful for treating PAF-mediated disorders, and can be used in methods for treating atherosclerosis and preventing or reducing risk for atherosclerotic disease events. The compounds are also useful for treating or ameliorating pain, e. g. inflammatory pain and/or nociceptive pain, and for treating or ameliorating autoimmune and/or inflammatory diseases, among other conditions.
Mark Goulet - Lexington MA, US Feroze Ujjainwalla - Scotch Plains NJ, US Anthony Ogawa - Mountainside NJ, US Derek Langen - Scotch Plains NJ, US
International Classification:
A61K031/7052 A61K031/397
US Classification:
514025000, 514210020, 536017400, 540200000
Abstract:
This invention provides cholesterol absorption inhibitors of Formula I: and the pharmaceutically acceptable salts and esters thereof. The compounds are useful for lowering plasma cholesterol levels, particularly LDL cholesterol, and for treating and preventing atherosclerosis and atherosclerotic disease events.
Lin Chu - Scotch Plains NJ, US Ihor Kopka - Hampton NJ, US Bing Li - Towaco NJ, US Anthony Ogawa - Mountainside NJ, US Feroze Ujjainwalla - Scotch Plains NJ, US
The instant invention provides compounds of formula I which are 5-lipoxygenase activating protein inhibitors. Compounds of formula I are useful as anti-atherosclerotic, anti-asthmatic, anti-allergic, anti-inflammatory and cytoprotective agents.
Merck Jan 2017 - Dec 2016
Principal Scientist
Merck Jun 2000 - Apr 2012
Research Fellow
The Scripps Research Institute Mar 1998 - Jun 2000
Nih Post-Doctoral Fellow
Education:
University of California, Los Angeles 1991 - 1997
Doctorates, Doctor of Philosophy, Organic Chemistry
University of California, Los Angeles 1992 - 1997
Doctorates, Doctor of Philosophy, Chemistry
Massachusetts Institute of Technology 1987 - 1991
Bachelors, Bachelor of Science, Chemistry
Skills:
Research
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