Ann T Poblenz

US Patent:

20070004748, Jan 4, 2007

Filed:

Jun 16, 2006

Appl. No.:

11/455272

Inventors:

Bryant Darnay - Houston TX, US
Janet Price - Missouri City TX, US
Ann Poblenz - Seattle WA, US
Moshe Talpaz - Houston TX, US

International Classification:

A61K 31/496
A61K 31/4709

US Classification:

514253060, 514313000

Abstract:

The present invention include methods and compositions for treating bone-resorbing diseases or bone resorption related to a pathologic condition generally, including, but not limited to osteoporosis, arthritis, rheumatoid arthritis, cancer metastases to the bone, bone cancer, hypercalcemia, osteolytic lesions with orthopedic implants, Paget's disease, and bone loss associated with hyperparathyroidism. Representative cancers include, but are not limited to breast cancer, prostrate cancer, colon cancer, endometrial cancer, multiple myeloma, renal cell carcinoma, heck and neck cancers, and cervical carcinoma. Arthritic conditions include, but are not limited to adjuvant-, collagen-, bacterial- and antigen-induced arthritis, particularly rheumatoid arthritis.

US Patent:

20090018146, Jan 15, 2009

Filed:

Jan 26, 2006

Appl. No.:

11/814268

Inventors:

Jordan Gutterman - Houston TX, US
Amos Gaikwad - Sugarland TX, US
Ann Poblenz - Playa Del Rey CA, US
Valsala Haridas - Pearland TX, US

Assignee:

Research Development Corporation - Carson City NV

International Classification:

A61K 31/4965
A61P 35/00

US Classification:

51425506

Abstract:

The present invention provides therapeutic compositions comprising a natural triterpenoid and a proteasome inhibitor. These compositions will be particularly useful in the treatment of malignancies and inflammation. The present invention also provides methods of treating a subject having a malignancy or an inflammatory disorder comprising administering to the subject a natural triterpenoid and a proteasome inhibitor.