Angus Mitchell Hucknall

US Patent:

20130157889, Jun 20, 2013

Filed:

May 17, 2011

Appl. No.:

13/698383

Inventors:

Ashutosh Chilkoti - Durham NC, US
Angus Hucknall - Durham NC, US

Assignee:

DUKE UNIVERSITY - Durham NC

International Classification:

G01N 33/543

US Classification:

506 9, 506 18, 506 30

Abstract:

Disclosed are devices and methods for detecting analytes from a sample.

US Patent:

20090247424, Oct 1, 2009

Filed:

Mar 17, 2009

Appl. No.:

12/405300

Inventors:

Ashutosh Chilkoti - Durham NC, US
Angus Hucknall - Durham NC, US

Assignee:

Duke University - Durham NC

International Classification:

C40B 30/04
C40B 40/08
C40B 40/10
C40B 50/18

US Classification:

506 9, 506 17, 506 18, 506 32

Abstract:

An article such as a biomolecular detector or biosensor having a nonfouling surface thereon includes:(a) a substrate having a surface portion; (b) a linking layer on the surface portion; and (c) a polymer layer formed on the linking layer; and (d) a first member of a specific binding pair (e.g., a protein, peptide, antibody, nucleic acid, etc.) bound to the polymer layer. Methods of making and using the articles are also described.

US Patent:

20230098149, Mar 30, 2023

Filed:

Sep 30, 2022

Appl. No.:

17/957373

Inventors:

- Durham NC, US
Jacob Heggestad - Durham NC, US
David Kinnamon - Durham NC, US
Angus Hucknall - Durham NC, US

International Classification:

G01N 33/569
G01N 21/64

Abstract:

Disclosed herein are devices that can be used to detect neutralizing antibodies against multiple pathogens in a quick and accurate manner. An example device includes a substrate; a non-fouling layer; a plurality of pathogen regions, each pathogen region including a different pathogen; and at least one detection region, the detection region including a detection agent that is capable of specifically binding each pathogen and an excipient. In addition, an example method includes contacting a biological sample with a device, and detecting the presence of a neutralizing antibody in the biological sample for each pathogen, wherein the presence of the neutralizing antibody is detected by inhibiting the binding of the detection agent to each pathogen.

US Patent:

20210011014, Jan 14, 2021

Filed:

Jul 27, 2020

Appl. No.:

16/939777

Inventors:

- Norcross GA, US
Angus HUCKNALL - Durham NC, US

International Classification:

G01N 33/543

Abstract:

An article such as a biomolecular detector or biosensor having a nonfouling surface thereon includes:(a) a substrate having a surface portion; (b) a linking layer on the surface portion; and (c) a polymer layer formed on the linking layer; and (d) a first member of a specific binding pair (e.g., a protein, peptide, antibody, nucleic acid, etc.) bound to the polymer layer. Methods of making and using the articles are also described.

US Patent:

20200378916, Dec 3, 2020

Filed:

Jun 1, 2017

Appl. No.:

16/305696

Inventors:

- Durham NC, US
Aaron Franklin - Durham NC, US
Benjamin Yellen - Durham NC, US
Angus Hucknall - Durham NC, US
Daniel Joh - Durham NC, US
Joseph Andrews - Durham NC, US

International Classification:

G01N 27/22
G01N 33/543
G01N 27/12

Abstract:

Disclosed are sensors that include a carbon nanotube channel and a non-fouling polymer layer, where the non-fouling polymer layer and the carbon nanotube channel do not directly contact each other and are separated by a dielectric layer. The disclosed sensors may be used, e.g., as biosensors for the accurate and sensitive detection of analytes within a sample. Also disclosed are methods of making and using the sensors.

US Patent:

20190391141, Dec 26, 2019

Filed:

Apr 17, 2019

Appl. No.:

16/387010

Inventors:

- Norcross GA, US
Angus Hucknall - Durham NC, US

International Classification:

G01N 33/543
A61B 5/15
A61B 5/151
A61B 5/157

Abstract:

Disclosed are devices and methods for detecting analytes from a sample.

US Patent:

20190285623, Sep 19, 2019

Filed:

Mar 27, 2019

Appl. No.:

16/366054

Inventors:

- NORCROSS GA, US
Angus Hucknall - Durham NC, US

International Classification:

G01N 33/543

Abstract:

An article such as a biomolecular detector or biosensor having a nonfouling surface thereon includes: (a) a substrate having a surface portion; (b) a linking layer on the surface portion; and (c) a polymer layer formed on the linking layer; and (d) a first member of a specific binding pair (e.g., a protein, peptide, antibody, nucleic acid, etc.) bound to the polymer layer. Methods of making and using the articles are also described.

US Patent:

20180217136, Aug 2, 2018

Filed:

Jul 15, 2016

Appl. No.:

15/746081

Inventors:

- Norcross GA, US
Angus Hucknall - Durham NC, US

International Classification:

G01N 33/543
G01N 33/574

Abstract:

Disclosed herein are chips, devices, methods of making the same, and methods of detecting a target analyte, and methods of diagnosing an individual with a disease or condition when a target analyte associated with the disease or condition is detected.