Andrew J Shoffstall

US Patent:

20140242180, Aug 28, 2014

Filed:

Oct 12, 2012

Appl. No.:

14/351807

Inventors:

- Cleveland OH, US
Andrew Shoffstall - Cleveland Heights OH, US
Jeffrey Ustin - Cleveland OH, US

International Classification:

A61K 9/14
A61K 47/48

US Classification:

424499, 525 541, 530331, 424 7817, 514 139, 428402

Abstract:

A temperature stable nanoparticle is provided comprising a core, a water soluble polymer and a peptide, the water soluble polymer attached to the core at a first terminus of the water soluble polymer, the peptide attached to a second terminus of the water soluble polymer, the peptide comprising an RGD amino acid sequence, the water soluble polymer of having sufficient length to allow binding of the peptide to glycoprotein lib/Ilia (GPIIb/llla). In one aspect, the nanoparticle has a melting temperature over 35 C. In various aspects, the nanoparticle has a spheroid shape and a diameter of less than 1 micron.