Andrew Marc Haidle from Truro, MA, age 49

Us Patents

Inhibitors Of Janus Kinases
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US Patent:

8278335, Oct 2, 2012
Filed:

Apr 9, 2009
Appl. No.:

12/988705
Inventors:

Michelle R. Machacek - Brookline MA, US
Andrew Haidle - Cambridge MA, US
Anna A. Zabierek - Boston MA, US
Kaleen M. Konrad - Boston MA, US
Michael D. Altman - Needham MA, US
Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ
International Classification:

A01N 43/40
A61K 31/44
US Classification:

514342, 51425205, 5462697, 544238
Abstract:

The instant invention provides for compounds that inhibit the four known mammalian JAK kinases (JAK1, JAK2, JAK3 and TYK2) and PDK1. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting the activity of JAK1, JAK2, JAK3, TYK2 and PDK1 by administering the compound to a patient in need of treatment for myeloproliferative disorders or cancer.

Inhibitors Of Janus Kinases
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US Patent:

8367706, Feb 5, 2013
Filed:

Jun 16, 2008
Appl. No.:

12/665045
Inventors:

Michael Altman - Cambridge MA, US
Matthew Christopher - Wallingford CT, US
Jonathan B. Grimm - Newton MA, US
Andrew Haidle - Cambridge MA, US
Kaleen Konrad - Newton MA, US
Jongwon Lim - Lexington MA, US
Rachel N. MacCoss - Brookline MA, US
Michelle Machacek - Brookline MA, US
Ekundayo Osimboni - Ashland MA, US
Ryan D. Otte - Natick MA, US
Tony Siu - Brookline MA, US
Kerrie Spencer - Woonsocket RI, US
Brandon Taoka - Allston MA, US
Paul Tempest - Brookline MA, US
Kevin Wilson - West Newton MA, US
Hyun Chong Woo - Brookline MA, US
Jonathan Young - Southborough MA, US
Anna Zabierek - Salem MA, US
Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ
International Classification:

A61K 31/4436
C07D 409/12
US Classification:

514336, 5462814
Abstract:

The instant invention provides for compounds that inhibit the four known mammalian JAK kinases (JAK1, JAK2, JAK3 and TYK2) and PDK1. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting the activity of JAK1, JAK2, JAK3 TYK2 and PDK1 by administering the compound to a patient in need of treatment for myeloproliferative disorders or cancer.

Inhibitors Of Janus Kinases
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US Patent:

8420695, Apr 16, 2013
Filed:

Jul 1, 2009
Appl. No.:

13/002776
Inventors:

Kevin Wilson - West Newton MA, US
Gabriela de Almeida - Brookline MA, US
Andrew Haidle - Cambridge MA, US
Kaleen Konrad - Newton MA, US
Michelle Machacek - Brookline MA, US
Ann Zabierek - Watertown MA, US
Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ
International Classification:

A61K 31/38
C07D 333/36
C07D 333/42
US Classification:

514447, 549 68
Abstract:

The instant invention provides for compounds that inhibit the four known mammalian JAK kinases (JAK1, JAK2, JAK3 and TYK2). The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting the activity of JAK1, JAK2, JAK3 and TYK2 by administering the compound to a patient in need of treatment for myeloproliferative disorders or cancer.

Aminopyrimidines As Syk Inhibitors
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US Patent:

8551984, Oct 8, 2013
Filed:

Dec 15, 2010
Appl. No.:

12/968608
Inventors:

Michael D. Altman - Needham MA, US
Brian M. Andresen - Sharon MA, US
Kenneth L. Arrington - Revere MA, US
Jason Burch - Westmount, CA
Kaleen Konrad Childers - Newton MA, US
Bernard Cote - Notre-Dame-de-l'lle-Perrot, CA
Maria Emilia Di Francesco - Brookline MA, US
Anthony Donofrio - Cambridge MA, US
Kristina Dupont-Gaudet - Vaudreuil-Dorion, CA
John Michael Ellis - Needham MA, US
Christian Fischer - Natick MA, US
Daniel Guay - Lachine, CA
David Joseph Guerin - Natick MA, US
Andrew M. Haidle - Cambridge MA, US
Solomon Kattar - Arlington MA, US
Sandra Lee Knowles - Boston MA, US
Chaomin Li - Boston MA, US
Jongwon Lim - Lexington MA, US
Michelle R. Machacek - Brookline MA, US
Alan B. Northrup - Reading MA, US
Brendan M. O'Boyle - Boston MA, US
Ryan D. Otte - Natick MA, US
Michael H. Reutershan - Brookline MA, US
Eric Romeo - Alliston MA, US
Adam J. Schell - Newton MA, US
Tony Siu - Brookline MA, US
Kerrie B. Spencer - Woonsocket RI, US
Brandon M. Taoka - Brookline MA, US
B. Wesley Trotter - Newton Highland MA, US
Hua Zhou - Acton MA, US
Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ
Merck Canada Inc. - Kirkland, Quebec
International Classification:

C07D 417/12
A61K 31/497
US Classification:

51421208, 51421706, 5142358, 51425202, 51425219, 514275, 540524, 540601, 544122, 544238, 544295, 544296, 544331
Abstract:

The present invention provides novel pyrimidine amines of formula (I) which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD and rheumatoid arthritis.

Inhibitors Of Janus Kinases
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US Patent:

20090306071, Dec 10, 2009
Filed:

Jun 5, 2007
Appl. No.:

12/227959
Inventors:

Jonathan R. Young - Southborough MA, US
Andrew Haidle - Cambridge MA, US
Paul Tempest - Brookline MA, US
Michelle Machacek - Boston MA, US
International Classification:

A61K 31/5377
A61K 31/497
A61K 31/4745
C07D 471/04
US Classification:

5142328, 51425302, 514287, 544125, 544361, 546 64
Abstract:

The instant invention provides for compounds that inhibit the four known mammalian JAK kinases (JAK1, JAK2, JAK3 and TYK2) and PDK1. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting the activity of JAK1, JAK2, JAK3 TYK2 and PDK1 by administering the compound to a patient in need of treatment for myeloproliferative disorders or cancer.

Heterocycles Useful As Inhibitors Of Carbonic Anhydrase
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US Patent:

20100256357, Oct 7, 2010
Filed:

Jul 30, 2007
Appl. No.:

12/376677
Inventors:

Wesley Kwan Mung Chong - Encinitas CA, US
Andrew M. Haidle - Cambridge MA, US
Martha Alicia Ornelas - San Diego CA, US
Lin Li - Shanghai, CN
Seiji Nukui - San Diego CA, US
Eugene Yuanjin Rui - San Diego CA, US
Min Teng - San Diego CA, US
William Francois Vernier - Oceanside CA, US
Joe Zhongxiang Zhou - San Diego CA, US
International Classification:

C07D 413/06
C07D 249/12
C07D 413/12
C07D 401/06
C07D 403/06
US Classification:

540544, 5482668, 544132, 5462724, 544366, 544105
Abstract:

Sulfonamides and pharmaceutical compositions containing the compounds useful in controlling intraocular pressure are disclosed. Methods for controlling intraocular pressure through administration of the compositions are also disclosed.

Aminopyrimidines As Syk Inhibitors
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US Patent:

20120277192, Nov 1, 2012
Filed:

Dec 15, 2010
Appl. No.:

13/516455
Inventors:

Michael D. Altman - Needham MA, US
Brian M. Andresen - Sharon MA, US
Kenneth L. Arrington - Revere MA, US
Sathesh Bhat - Dollard-des-Ormeaux, CA
Jason Burch - Redwood City CA, US
Kaleen Konrad Childers - Newton MA, US
Bernard Cote - Notre-Dame-de-I'Ile-Perrot, CA
Maria Emilia Di Francesco - Houston TX, US
Anthony Donofrio - Cambridge MA, US
Kristina Dupont-Gaudet - Vaudreuil-Dorion, CA
John Michael Ellis - Needham MA, US
Christian Fischer - Natick MA, US
Jean-Francois Fournier - Montreal, CA
Jacques Yves Gauthier - Laval, CA
Jonathan Grimm - Asburn VA, US
Daniel Guay - Lachine, CA
David Joseph Guerin - Natick MA, US
Andrew M. Haidle - Cambridge MA, US
Solomon Kattar - Arlington MA, US
Sandra Lee Knowles - Princeton NJ, US
Chaomin Li - Boston MA, US
Jongwon Lim - Lexintong MA, US
Michelle R. Machacek - Brookline MA, US
Matthew L. Maddess - Boston MA, US
Alan B. Northrup - Reading MA, US
Brendan M. O'Boyle - Boston MA, US
Ryan D. Otte - Natick MA, US
Alessia Petrocchi - Houston TX, US
Michael H. Reutershan - Brookline MA, US
Joel S. Robichaud - Dollar-des-Ormeaux, CA
Eric Romeo - Allston MA, US
Adam J. Schell - Decatur GA, US
Tony Siu - Brookline MA, US
Kerrie B. Spencer - Woonsocket RI, US
Brandon M. Taoka - Hoboken NJ, US
B. Wesley Trotter - Newton Highlands MA, US
Hyun Chong Woo - Natick MA, US
Hua Zhou - Acton MA, US
International Classification:

A61K 31/506
A61K 31/55
A61K 31/554
A61K 31/551
A61P 35/00
C07D 417/14
C07F 9/6539
C07D 417/12
A61P 19/02
A61P 11/06
A61K 31/675
A61K 31/5377
US Classification:

514 86, 5142102, 51421202, 51421208, 514218, 5142358, 514249, 514275, 540488, 540492, 540524, 544123, 544243, 544321
Abstract:

The present invention provides novel pyrimidine amines of formula (I) which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD and rheumatoid arthritis.

Aza-Benzothiophene Compounds As Sting Agonists
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US Patent:

20210009608, Jan 14, 2021
Filed:

Mar 28, 2019
Appl. No.:

17/040192
Inventors:

Michael D. ALTMAN - Boston MA, US
Brandon D. CASH - Boston MA, US
Jared N. CUMMING - Boston MA, US
Duane E. DEMONG - Boston MA, US
Andrew M. HAIDLE - Boston MA, US
James P. JEWELL - Boston MA, US
Matthew A. LARSEN - Boston MA, US
Min LU - Boston MA, US
Ryan D. OTTE - Boston MA, US
Brandon M. TAOKA - South San Francisco CA, US
Benjamin Wesley TROTTER - Boston MA, US
Quang T, TRUONG - Kenilworth NJ, US
- Rahway NJ, US
Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ
International Classification:

C07D 513/04
C07D 495/04
A61P 37/04
Abstract:

Compounds of general formula (I), and their pharmaceutically acceptable salts, wherein R, R, R, R, R, R, R, A, X, X, and Xare defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are compositions comprising such compounds, processes for the synthesis of such compounds, and to uses of such compounds, including administration of such compounds to induce immune response, to induce STING-dependent type I interferon production, and/or to treat a cell proliferation disorder, such as cancer.