Andrew J Brightman

Deceased

from Battle Ground, IN

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Andrew Brightman Phones & Addresses

Submucosa Extracts
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US Patent:

6375989, Apr 23, 2002
Filed:

Jun 10, 1999
Appl. No.:

09/319656
Inventors:

Stephen F. Badylak - West Lafayette IN
Andrew O. Brightman - West Lafayette IN
Jason P. Hodde - West Lafayette IN
Timothy B. McPherson - Granite City IL
Assignee:

Purdue Research Foundation - West Lafayette IN
International Classification:

A61K 3538
US Classification:

424551, 514 2, 514 21
Abstract:

A method for preparing a bioactive extract from warm-blooded vertebrate submucosal tissue is described. The submucosal tissue is extracted using an aqueous solution of extraction excipients, and the extracted bioactive components are then separated from the extraction excipients to provide an isolated extract enriched in bioactive components. The isolated extract is useful, inter alia, as additive for cell growth media to promote cell growth and proliferation in vitro.

Submucosa Gel Compositions
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US Patent:

6444229, Sep 3, 2002
Filed:

Jul 23, 2001
Appl. No.:

09/911144
Inventors:

Andrew O. Brightman - West Lafayette IN
Ryan M. Meixner - Minnetonka MN
Beverly Z. Waisner - Lafayette IN
Assignee:

Purdue Research Foundation - West Lafayette IN
International Classification:

A61K 3537
US Classification:

424551, 424520, 424550, 435391
Abstract:

A composition comprising enzymatically digested submucosa of a warm-blooded vertebrate and a method of making that composition is described. More particularly the submucosa is enzymatically digested and gelled to form a shape retaining gel matrix suitable for inducing cell proliferation and growth both in vivo and in vitro.

Submucosa Gel Compositions
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US Patent:

7147871, Dec 12, 2006
Filed:

Sep 3, 2002
Appl. No.:

10/233888
Inventors:

Andrew O. Brightman - West Lafayette IN, US
Ryan M. Meixner - Minnetonka MN, US
Beverly Z. Waisner - Lafayette IN, US
Assignee:

Purdue Research Foundation - West Lafayette IN
International Classification:

A61K 35/37
A61K 35/38
C12P 21/06
US Classification:

424551, 435 681
Abstract:

A composition comprising enzymatically digested submucosa of a warm-blooded vertebrate and a method of making that composition is described. More particularly the submucosa is enzymatically digested and gelled to form a shape retaining gel matrix suitable for inducing cell proliferation and growth both in vivo and in vitro.

Growth Factor Modified Extracellular Matrix Material Preparation And Methods For Preparation And Use Thereof
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US Patent:

8591930, Nov 26, 2013
Filed:

Apr 28, 2008
Appl. No.:

12/110630
Inventors:

Michael C. Hiles - Lafayette IN, US
Andrew Brightman - West Lafayette IN, US
Abram D. Janis - Valencia CA, US
Assignee:

Cook Biotech Incorporated - West Lafayette IN
International Classification:

A61F 2/00
US Classification:

424423, 424574, 514 2, 514 12
Abstract:

Described are tissue graft constructs that include submucosa and other extracellular matrix materials that incorporate a number of exogenous proteins. Further described are methods for making tissue graft constructs that include stripping endogenous heparin binding proteins from a porcine graft material and thereafter binding one or more human growth factors to the native heparin molecules that are retained within the graft material. Such graft materials may be used in methods for the treatment of wounds in patients.

Submucosa Gel Compositions
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US Patent:

20030012822, Jan 16, 2003
Filed:

Sep 3, 2002
Appl. No.:

10/233881
Inventors:

Andrew Brightman - West Lafayette IN, US
Ryan Meixner - Minnetonka MN, US
Beverly Waisner - Lafayette IN, US
International Classification:

A61K035/37
US Classification:

424/550000
Abstract:

A composition comprising enzymatically digested submucosa of a warm-blooded vertebrate and a method of making that composition is described. More particularly the submucosa is enzymatically digested and gelled to form a shape retaining gel matrix suitable for inducing cell proliferation and growth both in vivo and in vitro.

Submucosa As A Growth Substrate For Cells
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US Patent:

62649922, Jul 24, 2001
Filed:

Aug 15, 2000
Appl. No.:

9/622244
Inventors:

Andrew O. Brightman - West Lafayette IN
Ryan M. Meixner - Minnetonka MN
Beverly Z. Waisner - Lafayette IN
Assignee:

Purdue Research Foundation - West Lafayette IN
International Classification:

C12N 500
US Classification:

424551
Abstract:

A composition comprising enzymatically digested submucosa of a warm-blooded vertebrate and a method of making that composition is described. More particularly the submucosa is enzymatically digested and gelled to form a shape retaining gel matrix suitable for inducing cell proliferation and growth both in vivo and in vitro.

Stomach Submucosa Derived Tissue Graft
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US Patent:

6099567, Aug 8, 2000
Filed:

May 4, 1999
Appl. No.:

9/297624
Inventors:

Stephen F. Badylak - West Lafayette IN
Andrew O. Brightman - West Lafayette IN
Robert S. Tullius - Brookston IN
Assignee:

Purdue Research Foundation - West Lafayette IN
International Classification:

A61F 208
A61F 3537
US Classification:

623 13
Abstract:

A tissue graft composition comprising stomach submucosal tissue delaminated from both the luminal portion of the tunica mucosa and the smooth muscle layers of the muscularis externa of a stomach of a warm blooded vertebrate is described. The graft composition can be or implanted into a host to replace or support damaged or diseased tissues.

Gastric Submucosal Tissue As A Novel Diagnostic Tool
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US Patent:

20100041135, Feb 18, 2010
Filed:

Jul 15, 2009
Appl. No.:

12/503774
Inventors:

Stephen F. Badylak - Pittsburgh PA, US
George B. Boder - Martinsville IN, US
Matthew S. Waninger - Lafayette IN, US
Andrew O. Brightman - Battleground IN, US
International Classification:

C12N 5/07
US Classification:

435325
Abstract:

A cell culture growth substrate comprising submucosal tissue of a warm-blooded vertebrate and a method for culturing fastidious organisms is described. Submucosal tissue used in accordance with the present invention supports the proliferation of cells when said cells are contacted with submucosal tissue under conditions conducive to cell proliferation.