Anandi Mahadevan

US Patent:

20080262367, Oct 23, 2008

Filed:

Apr 4, 2008

Appl. No.:

12/062551

Inventors:

Dale H. Mugler - Hudson OH, US
Soumyadipta Acharya - Baltimore MD, US
Raghavan Gopalakrishnan - Parma OH, US
Anandi Mahadevan - Akron OH, US

Assignee:

THE UNIVERSITY OF AKRON - Akron OH

International Classification:

A61B 5/0402
A61B 5/0476

US Classification:

600523, 600544

Abstract:

The present invention relates to general diagnostic and real-time applications of discrete Hermite functions to digital data. More specifically, the invention relates to methods and systems for the application of dilated discrete digital Hermite functions (DDHF) to biomedical data, for example, to extract features from digital signals, including but not limited to, ECGs, EMGs, EOGs, EEGs, and others, by expanding the measured signals using a computationally efficient technique. These digital Hermite functions form the basis for the new discrete Hermite transform, generated on a beat by beat basis, which provides information about the shape of the signals, such as that in the BCG artifact in an EEG or in an ECG interval, or any noise in any other electrical signal. An automated system and method for real-time interpretation of any abnormalities present in a digital biomedical signal is provided.

US Patent:

20140000611, Jan 2, 2014

Filed:

Mar 13, 2012

Appl. No.:

14/005389

Inventors:

William A. Truschel - Oakmont PA, US
Anandi Mahadevan - Monroeville PA, US
Christopher Anthony Procyk - New Kensington PA, US
Mark Christopher McDermott - Pittsburgh PA, US

International Classification:

A61B 5/00
A61M 16/00

US Classification:

12820423

Abstract:

Sleep apnea can be treated using positive airway pressure. Methods and systems for determining a level of airway obstruction allow beneficial adjustments to the level of expiratory positive airway pressure used to treat a subject.

US Patent:

20210128867, May 6, 2021

Filed:

Dec 27, 2017

Appl. No.:

16/472621

Inventors:

- EINDHOVEN, NL
Surya Subrahmanya Sreeram VISSAPRAGADA VENKATA SATYA - Monroeville PA, US
Stefan PFUNDTNER - Eindhoven, NL
Tsvetomira Kirova TSONEVA - Eindhoven, NL
Anandi MAHADEVAN - Murrysville PA, US

International Classification:

A61M 21/02

Abstract:

The present disclosure pertains to a system and method for determining whether a subject is likely to be disturbed by therapy levels of stimulation provided to the subject during sleep sessions. The present system is configured to automatically identify sensitive users using electroencephalogram (EEG) information from a reference sleep session with or without stimulation. For reference sleep sessions without stimulation, the alpha activity in detected deep sleep is used to predict whether the subject is likely to be disturbed by therapy levels of stimulation. For reference sleep sessions with stimulation, the acute increase in EEG delta (e.g., 0.5-4 Hz) power and/or an arousability index are used to predict whether the subject is likely to be disturbed by therapy levels of stimulation.

US Patent:

20200077919, Mar 12, 2020

Filed:

Dec 1, 2017

Appl. No.:

16/466357

Inventors:

- EINDHOVEN, NL
Anandi MAHADEVAN - Murrysville PA, US
Surya Subrahmanya Sreeram VISSAPRAGADA VENKATA SATYA - Monroeville PA, US
Annette KAPITAN - Monroeville PA, US

International Classification:

A61B 5/0484
A61B 5/00
A61M 21/00

Abstract:

The present disclosure pertains to a reference slow wave activity metric determination system. Instead of collecting information during sleep sessions without stimulation (e.g., baseline and/or sham sessions) to determine a reference amount of slow wave activity in a subject, the present system is configured to build a model between stimulation properties and slow wave enhancement, and determine the reference amount of slow wave activity in the subject (e.g., corresponding to what would occur during baseline sleep and/or sham sessions) using the model. Advantageously, this approach does not require performance of baseline and/or sham sleep sessions, and enables personalization of the reference amount of slow wave activity, which dynamically increases its accuracy as more information is collected.

US Patent:

20190343455, Nov 14, 2019

Filed:

Dec 21, 2017

Appl. No.:

16/470791

Inventors:

- EINDHOVEN, NL
Tsvetomira Kirova TSONEVA - Eindhoven, NL
Stefan PFUNDTNER - Eindhoven, NL
Surya Subrahmanya Sreeram VISSAPRAGADA VENKATA SATYA - Monroeville PA, US
Anandi MAHADEVAN - Murrysville PA, US
Diana KOSOBUD - Montgomery OH, US

International Classification:

A61B 5/00
A61B 5/048
A61M 21/02

Abstract:

The present disclosure pertains to a system configured to output an indicator representative of effects of stimulation provided to a subject during a sleep session. The indicator is determined based on a combination of the effect of stimulation on sleep restoration, stimulation quality, sleep architecture factors, and/or other information. The indicator is determined using age matched reference information on deep sleep duration and EEG slow wave activity. The contribution to the indicator associated with sleep architecture factors is determined based on age matched reference information including sleep onset latency, wake after sleep onset, total sleep time, micro-arousal count, sleep stage(s) prior to awakening, and/or other information.

US Patent:

20190336723, Nov 7, 2019

Filed:

Dec 7, 2017

Appl. No.:

16/466794

Inventors:

- EINDHOVEN, NL
Anandi MAHADEVAN - Murrysville PA, US
Surya Subrahmanya Sreeram VISSAPRAGADA VENKATA SATYA - Monroeville PA, US

International Classification:

A61M 21/02
A61B 5/00
A61B 5/0476

Abstract:

The present disclosure pertains to determining timing of stimulation provided to a subject during sleep. The system receives a raw signal carrying information related to slow wave activity; buffers a portion of the raw signal; determines a timing of slow wave events in the buffered portion of the raw signal; filters the raw signal; determines a timing of slow wave events in the filtered raw signal; compares the timing of the slow wave events in the buffered portion of the raw signal to the timing of the slow wave events in the filtered raw signal; determines a first correction factor associated with reducing slow wave activity in the subject and a second correction factor associated with enhancing slow wave activity in the subject; and adjusts a timing of the stimulation provided to the subject during the sleep session based on the first and/or second correction factors.

US Patent:

20190083028, Mar 21, 2019

Filed:

Jun 14, 2018

Appl. No.:

16/008102

Inventors:

- EINDHOVEN, NL
Edouard Robert Marcus GEBSKI - Pittsburgh PA, US
Mark CHOI - Monroeville PA, US
Annette KAPITAN - Monroeville PA, US
Stefan PFUNDTNER - Eindhoven, NL
Tsvetomira Kirova TSONEVA - Eindhoven, NL
Anandi MAHADEVAN - Murrysville PA, US
Megan KING - Pittsburgh PA, US
Diane KOSOBUD - Montgomery OH, US
Jessica WEEDEN - Monroeville PA, US
Guy Anthony BROWN - Haarlem, NL

International Classification:

A61B 5/00

Abstract:

The present disclosure pertains to facilitating sleep improvement for a user. In a non-limiting embodiment, user data associated with a sleep session of a user is received from one or more sensors. Based on the user data, one or more sleep metrics associated with the sleep session are generated. One or more reference sleep metrics are determined based on prior user data obtained from one or more prior sleep sessions. One or more immediate values related to the sleep session is/are determined based on a comparison of the sleep metrics with the reference sleep metrics. A sleep session score value is generated based on the immediate values, and the sleep session score value and the sleep metrics are caused to be presented on via an output device.

US Patent:

20180361110, Dec 20, 2018

Filed:

Dec 8, 2016

Appl. No.:

16/062721

Inventors:

- EINDHOVEN, NL
Anandi MAHADEVAN - Murrysville PA, US
Surya Subrahmanya Sreeram VISSAPRAGADA VENKATA SATYA - Monroeville PA, US
John GERTHOFFER - Monroeville PA, US

International Classification:

A61M 21/02
A61B 5/0484
A61B 5/0478

Abstract:

The present disclosure pertains to a system configured to adjust an intensity of sensory stimulation delivered to a subject during a sleep session based on sleep depth in the subject during the sleep session. The restorative value of sleep may be increased by enhancing sleep slow-waves using sensory stimulation. The stimulation may be applied at an appropriate timing and/or intensity to enhance sleep slow-waves to enhance slow-waves without disturbing sleep.