Amita Goel

from Plano, TX

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Amita Goel Phones & Addresses

Plano, TX
Dallas, TX
Irving, TX
Santa Clara, CA

Work

Company:

Gilead biosciences/arresto biosciences, foster city
2010
Position:

Research scientist ii, biologics pd and manufacturing

Education

School / High School:

SAN JOSE STATE UNIVERSITY- San Jose, CA
Specialities:

Master of Science in Microbiology Thesis

Skills

HIGHLIGHTS OF TECHNICAL SKILLS Cloning • bacterial expression • mammalian expression involving generatin... • adherent and suspension cell lines • surface expression of proteins and cells... • and cell line development. Experti... • such as FACS and ELISA. Competent in var... • as part of cell line development • to .increase titers at various scales fr... • such as expression of adherent cell line... • overseeing technical transfer of process... • crystallization efforts • proof of concept • validation of certain targets • high-throughput screening of compounds a...

Resumes

Amita Goel

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Amita Goel Pleasanton, CA

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Work:

GILEAD BIOSCIENCES/ARRESTO BIOSCIENCES, Foster City

2010 to 2000
Research Scientist II, Biologics PD and Manufacturing ELAN PHARMACEUTICALS

2007 to 2010
Manager/Scientist ELAN PHARMACEUTICALS
South San Francisco, CA
2002 to 2010 ELAN PHARMACEUTICALS

2002 to 2007
Associate Scientist PURDUE PHARMA
Irvine, CA
2001 to 2002
Senior Research Associate II, Molecular and Cell Biology NEXELL THERAPEUTICS
Irvine, CA
1999 to 2001
Senior Research Associate I, Gene Therapy Group BECKMAN COULTER (Hybritech)
San Diego, CA
1993 to 1999
Research Associate CYTEL CORPORATION
San Diego, CA
1991 to 1993
Research Associate I, Molecular Biology SCRIPPS RESEARCH INSTITUTE
La Jolla, CA
1990 to 1991
Research Tech II

Education:

SAN JOSE STATE UNIVERSITY
San Jose, CA
Master of Science in Microbiology Thesis TEXAS TECH UNIVERSITY
Lubbock, TX
Bachelor of Science in Microbiology

Skills:

HIGHLIGHTS OF TECHNICAL SKILLS Cloning, bacterial expression, mammalian expression involving generating stable cell lines, adherent and suspension cell lines, surface expression of proteins and cells lines that secrete proteins, and cell line development. Expertise in all aspects of gene expression. Adept at generation of highly-expressive cell lines. Proficient in cell line characterization and protein quantitation methods, such as FACS and ELISA. Competent in various assay development methods. Performing stability testing and media optimization, as part of cell line development, to .increase titers at various scales from shake flasks to bioreactors). Developing additional processes in cell culture, such as expression of adherent cell lines on micro-carrier beads. Freeze-thawing cells in novel way on beads to increase productivity. Facilitating cell line optimization in WAVE and Applikon bioreactors. Beta testing of new bioreactor for perfusion from Sepragen. Scaling up to >300L in WAVE bioreactors internally, overseeing technical transfer of processes to contract manufacturing organizations (CMO). Creating process to scale up from bench scale to 100L and to 2000L bioreactors to produce GMP grade proteins. Generating proteins from cell lines for developing cell-based assays, crystallization efforts, proof of concept, validation of certain targets, high-throughput screening of compounds as specific inhibitors for various targets. Neutralizing or blocking antibodies for in-vivo studies in animal models. Performing PK studies in animals and toxicology studies in rats and monkeys for phase 1 and phase 2 clinical trials in humans.

Amita Goel

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Us Patents

Compositions Of Glipr Fusion Proteins And Methods For The Treatment Of Prostate Cancer
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US Patent:

20200048319, Feb 13, 2020
Filed:

Aug 7, 2019
Appl. No.:

16/534285
Inventors:

- Houston TX, US
Amita Saxena Goel - Pleasanton CA, US
Divya Goel - Pleasanton CA, US
Assignee:

Glipper Oncology Research, Inc. - Houston TX
International Classification:

C07K 14/47
A61K 47/68
A61P 35/00
Abstract:

This invention is directed to fusion proteins comprised of one or more protein sequences of the glioma pathogenesis-related (GLIPR) family of proteins coupled to non-GLIPR protein sequences, to nucleic acid constructs and vectors comprising encoding fusion proteins and peptides, and to methods related to fusion proteins and peptides in the treatment of diseases. In particular, the invention is directed to GLIPR sequences coupled to sequences of antibodies and/or other immune system proteins and peptides, and methods related to fusion proteins in the treatment of prostate cancer.

Chimeric Post-Transcriptional Regulatory Element
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US Patent:

20190309322, Oct 10, 2019
Filed:

Dec 11, 2018
Appl. No.:

16/216636
Inventors:

- Union City CA, US
Amita Goel - Union City CA, US
International Classification:

C12N 15/85
C07K 16/28
Abstract:

The present disclosure relates to chimeric post-transcriptional regulatory elements (PRE) and vectors useful for expressing a protein in a cell. The PRE contains alpha, beta and optionally gamma subelements selected from different native PRE sequences and are discovered to be more potent than their native counterparts.

Methods And Compositions For Expression Of Polypeptides In A Cell
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US Patent:

20180030496, Feb 1, 2018
Filed:

Oct 11, 2017
Appl. No.:

15/730569
Inventors:

- Union City CA, US
Amita Goel - Union City CA, US
International Classification:

C12P 21/02
C12N 15/86
Abstract:

Disclosed herein are vector systems for expression of polypeptides in eukaryotic cells; and methods of obtaining high-level expression of polypeptides in a eukaryotic cell. Methods and compositions for obtaining stable, long-term expression of recombinant polypeptides are also provided

Chimeric Post-Transcriptional Regulatory Element
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US Patent:

20170114363, Apr 27, 2017
Filed:

Oct 27, 2016
Appl. No.:

15/335930
Inventors:

- Union City CA, US
Amita Goel - Union City CA, US
International Classification:

C12N 15/85
C07K 16/28
Abstract:

The present disclosure relates to chimeric post-transcriptional regulatory elements (PRE) and vectors useful for expressing a protein in a cell. The PRE contains alpha, beta and optionally gamma subelements selected from different native PRE sequences and are discovered to be more potent than their native counterparts.

Methods And Compositions For Expression Of Polypeptides In A Cell
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US Patent:

20170101658, Apr 13, 2017
Filed:

Jul 20, 2015
Appl. No.:

14/803813
Inventors:

Amita Goel - Union City CA, US
Assignee:

Celltheon Corporation - Hayward CA
International Classification:

C12P 21/02
C12N 15/86
Abstract:

Disclosed herein are vector systems for expression of polypeptides in eukaryotic cells; and methods of obtaining high-level expression of polypeptides in a eukaryotic cell. Methods and compositions for obtaining stable, long-term expression of recombinant polypeptides are also provided