Alfio F Fichera

US Patent:

7371867, May 13, 2008

Filed:

Nov 6, 2006

Appl. No.:

11/593443

Inventors:

Alfio Fichera - Malden MA, US
Zihni Bilgicer - Somerville MA, US
Krishna Kumar - Cambridge MA, US
Xuechao Xing - Wilmington MA, US

Assignee:

Trustees of Tufts College - Medford MA

International Classification:

C07D 211/82
C07C 327/40
C07C 237/30

US Classification:

546340, 558256, 560 19, 560 43, 560 47, 560 48, 560155, 560156, 560172, 562433, 562450, 562456, 562457, 562553

Abstract:

One aspect of the invention relates to hexafluoroleucine and congeners thereof, and methods of making the compounds. Another aspect of the invention relates to the synthesis of protein cores comprising hexafluoroleucine and congeners thereof. Certain peptides comprising hexafluoroleucine and congeners thereof have been characterized using comparative biophysical studies. In general, the fluorinated peptides show higher thermal stability and enhanced resistance to chemical denaturation. Further, mixed hydrocarbon-fluorocarbon cores self-sort into homogeneous bundles, suggesting new avenues for the design and manipulation of protein-protein interfaces.

US Patent:

20040138493, Jul 15, 2004

Filed:

Mar 15, 2004

Appl. No.:

10/468574

Inventors:

Alfio Fichera - Malden MA, US
Zihni Bilgicer - Somerville MA, US
Krishna Kumar - Cambridge MA, US
Xuechao Xing - Wilmington MA, US

International Classification:

C07C327/30
C07C237/20

US Classification:

558/256000, 560/156000, 562/553000, 564/163000

Abstract:

One aspect of the invention relates to hexafluoroleucine and congeners thereof, and methods of making the compounds. Another aspect of the nvention relates to the synthesis of protein cores comprising hexafluoroleucine and congeners thereof. Certain peptides comprising hexafluorleucine and congeners thereof have been characterized using comparative biophysical studies. In general, the fluorinated peptides show higher thermal stability and enhanced resistance to chemical denaturation. Further, mixed hydrocarbonfluorocarbon cores self-sort into homogeneous bundles, suggesting new avenues for the design and manipulation of protein-protein interfaces.