Aftab R Kherani

US Patent:

20090088482, Apr 2, 2009

Filed:

Oct 13, 2004

Appl. No.:

11/885391

Inventors:

Simon Maybaum - White Plains NY, US
Jie Wang - Englewood Cliffs NJ, US
Mehmet C. Oz - Cliffside Park NJ, US
Steve Xydas - Ardsley NY, US
Aftab Kherani - New York NY, US

Assignee:

The Trustees Of Columbia University In The City New York - New York NY

International Classification:

A61K 31/138

US Classification:

514653

Abstract:

The present invention provides compositions and methods for the following: preventing and treating heart failure; preventing heart failure in a patient with a pre-heart failure condition; treating and preventing heart failure with ischemic and non-ischemic causes; treating and preventing heart failure in a subject status post myocardial infarction; reversing damage to the heart following myocardial infarction; by administering to a subject an effective amount of an adrenergic beta-agonist either alone or in combination with an effective amount of an adrenergic beta-1 antagonist. FIG. is a bar graph representing relative infarct sizes, as expressed as a percentage of left ventricular circumference.