Adrian F Prokop

US Patent:

6594156, Jul 15, 2003

Filed:

Apr 24, 2000

Appl. No.:

09/556227

Inventors:

William P. Van Antwerp - Valencia CA
Sheana Karre - Lincoln NE
Adrian Prokop - Woodinville WA
Sara Akiko Stinson - Alameda CA
Jason Fong - Pleasant Hill CA
James J. Rosenberg - Monrovia CA

Assignee:

MiniMed Inc. - Sylmar CA

International Classification:

H05K 900

US Classification:

361816, 361800, 174 35 R, 174 35 MS, 2505051, 2505151, 53425, 257659

Abstract:

A circuit protection device for protection of sensitive components during high energy radiation sterilization that includes a support substrate and a protective housing. The substrate supports the sensitive components. The protective housing is hermetically coupled to the support substrate to seal the sensitive components within the protective housing. Preferably, the protective housing stops high energy used in the high energy sterilization from damaging the sensitive components from a predetermined exposure level of high energy sterilization. The circuit protection device may further include a protective conductor that is coupled to the support substrate on a side which is opposite the protective housing to prevent high energy from entering the opposite side of the support substrate. The circuit protection device can also include an energy absorbing material contained within an area sealed by the protective housing to absorb high energy by products produced by the protective housing stopping the high energy used in the high energy sterilization. Preferably, the support substrate is a circuit board, and the sensitive elements are semiconductors.

US Patent:

6880242, Apr 19, 2005

Filed:

Mar 6, 2003

Appl. No.:

10/382443

Inventors:

William P. Van Antwerp - Valencia CA, US
Sheana Karre - Lincoln NE, US
Adrian Prokop - Woodinville WA, US
Sara Akiko Stinson - Alameda CA, US
Jason Fong - Pleasant Hill CA, US
James J. Rosenberg - Monrovia CA, US

Assignee:

MiniMed Inc. - Sylmar CA

International Classification:

H05K003/30

US Classification:

29832, 29825, 29836, 29840

Abstract:

A circuit protection device for protection of sensitive components during high energy radiation sterilization that includes a support substrate and a protective housing. The substrate supports the sensitive components. The protective housing is hermetically coupled to the support substrate to seal the sensitive components within the protective housing. Preferably, the protective housing stops high energy used in the high energy sterilization from damaging the sensitive components from a predetermined exposure level of high energy sterilization. The circuit protection device may further include a protective conductor that is coupled to the support substrate on a side which is opposite the protective housing to prevent high energy from entering the opposite side of the support substrate. The circuit protection device can also include an energy absorbing material contained within an area sealed by the protective housing to absorb high energy byproducts produced by the protective housing stopping the high energy used in the high energy sterilization. Preferably, the support substrate is a circuit board, and the sensitive elements are semiconductors.

US Patent:

7070565, Jul 4, 2006

Filed:

May 30, 2003

Appl. No.:

10/449819

Inventors:

Shahram Vaezy - Seattle WA, US
Adrian Prokop - Lynnwood WA, US
Roy W. Martin - Anacortes WA, US
Peter Kaczkowski - Seattle WA, US
Misty Noble - Seattle WA, US

Assignee:

University of Washington - Seattle WA

International Classification:

A61B 8/14

US Classification:

600459

Abstract:

The present invention employs hydrogels as acoustic couplings for clinical applications of ultrasound imaging and therapy, but is particularly applicable to high intensity focused ultrasound (HIFU) based therapy. While other materials can be used, it has been determined that polyacrylamide is sufficiently robust and transmissive to withstand the high temperatures encountered in HIFU therapy. One embodiment of a hydrogel coupling is configured in shape and size (length) to ensure that a focal region of an ultrasound transducer is disposed proximate the target area when the distal tip of the transducer is in contact with tissue. These couplings can be shaped to correspond to the beam focus characteristics of specific transducers. Water can be applied to hydrate the tip of the hydrogel coupling during use, and medication absorbed into the hydrogel material can be applied to the tissue in contact with the distal surface of the hydrogel.

US Patent:

20020072661, Jun 13, 2002

Filed:

Dec 13, 2000

Appl. No.:

09/736603

Inventors:

William Wiesmann - Washington DC, US
Adrian Urias - Germantown MD, US
Jill Uyeno - Mission Viejo CA, US
Adrian Prokop - Seattle WA, US
Jason Milne - Eagan MN, US
Kristopher Jurka - Sherman Oaks CA, US
Farbod Ghassemi - Emerainville, FR

International Classification:

A61B005/00

US Classification:

600/328000, 600/342000, 600/549000

Abstract:

A system for assessing organ function has a plurality of light emitters of distinct spectral characteristics are coupled into a percutaneous fiber delivery assembly with a tip extending to or into an internal organ to illuminate organ tissue. The assembly includes a delivery optical fiber, and a collection fiber that collects and returns light scattered, reflected or emitted by the surrounding tissue to a detector at the proximal end. The device also senses temperature at the tip. Control and processing modules drive the laser diodes and process the return signals. The instrument may assess general metabolic activity by detecting light absorption of a linked substance, for example at a peak attributed to deoxygenated hemoglobin and/or at one or more peaks attributed to oxygenated hemoglobin. Preferably, change of a parameter such as pulse oxygen saturation together with one or more other parameters such as temperature are detected to provide an indication of organ function, e.g., the onset of shock. A prototype used four different laser diodes having peaks at 735, 760, 805 and 890 nm connected to a single optical fiber and driven at about 50 to 100 mW to illuminate organ tissue. A front-end splitter provides a reference beam to a photo detector to normalize the detection output in the return fiber, and dark current is subtracted to correct the signal samples. In other embodiments, a coupler may be fabricated from a multimode fiber with an SMA connector as an end coupler. The photo detector may be a broad band detector useful over a range, for example, of 320 to 1100 nanometers, and with a detection threshold of under a milliwatt. When used in a fluorescence mode the device may perform detection after filtering the diode or return signal with one or more narrow band filters, and the illumination and collection intervals may be offset to maximize signal collection or minimize interference. The percutaneous probe may be configured for catheter insertion or may have its fibers and electrical connections contained within a piercing sleeve that is itself capable of insertion directly through the skin and into an organ. Preferably, a control module allows the user to adjust data acquisition parameters and view the output signal quality as well as the measured or calculated parameters derived from the acquired signals. The processor may further control a firing sequence of the laser diodes, timing and size of the signal samples and data stores. The device may include a plurality of laser diodes of which only a portion are selected for each assay so as to tailor the spectral illumination to a different intended targeted enzyme, metabolite or other compound, and the processor may include heuristic correlators for interpreting the physiological state or detecting the onset of shock based on magnitudes of the multiple different measured parameters.

US Patent:

20060184074, Aug 17, 2006

Filed:

Mar 7, 2006

Appl. No.:

11/369281

Inventors:

Shahram Vaezy - Seattle WA, US
Adrian Prokop - Lynnwood WA, US
Roy Martin - Anacortes WA, US
Peter Kaczkowski - Seattle WA, US
Misty Noble - Seattle WA, US

Assignee:

University of Washington - Seattle WA

International Classification:

A61H 1/00
A61B 8/12

US Classification:

601002000, 600439000

Abstract:

The present invention employs hydrogels as acoustic couplings for clinical applications of ultrasound imaging and therapy, but is particularly applicable to high intensity focused ultrasound (HIFU) based therapy. While other materials can be used, it has been determined that polyacrylamide is sufficiently robust and transmissive to withstand the high temperatures encountered in HIFU therapy. One embodiment of a hydrogel coupling is configured in shape and size (length) to ensure that a focal region of an ultrasound transducer is disposed proximate the target area when the distal tip of the transducer is in contact with tissue. These couplings can be shaped to correspond to the beam focus characteristics of specific transducers. Water can be applied to hydrate the tip of the hydrogel coupling during use, and medication absorbed into the hydrogel material can be applied to the tissue in contact with the distal surface of the hydrogel.

US Patent:

20070265560, Nov 15, 2007

Filed:

Apr 24, 2007

Appl. No.:

11/739629

Inventors:

Azita Soltani - Snohomish WA, US
Adrian Prokop - Seattle WA, US

Assignee:

EKOS CORPORATION - Bothwell WA

International Classification:

A61N 7/00

US Classification:

604022000, 604093010

Abstract:

In one embodiment of the present invention, a system for treating an occlusion within a patient's vasculature with ultrasonic energy comprises a catheter configured to be passed through the patient's vasculature such that a portion of the catheter is positioned at an intravascular treatment site. The system further comprises an ultrasound radiating member, an ultrasound signal generator configured to supply a drive signal to the ultrasound radiating member, an infusion pump configured to pump a therapeutic compound into the fluid delivery lumen so as to cause the therapeutic compound to be delivered to the treatment site and a controller configured to control the ultrasound signal generator and the infusion pump.

US Patent:

20110264031, Oct 27, 2011

Filed:

Jul 5, 2011

Appl. No.:

13/176613

Inventors:

Azita Soltani - Snohomish WA, US
Adrian F. Prokop - Seattle WA, US

Assignee:

EKOS CORPORATION - Bothell WA

International Classification:

A61N 7/00
B23P 11/00
A61M 25/00

US Classification:

604 22, 29428

Abstract:

In one embodiment of the present invention, a system for treating an occlusion within a patient's vasculature with ultrasonic energy comprises a catheter configured to be passed through the patient's vasculature such that a portion of the catheter is positioned at an intravascular treatment site. The system further comprises an ultrasound radiating member, an ultrasound signal generator configured to supply a drive signal to the ultrasound radiating member, an infusion pump configured to pump a therapeutic compound into the fluid delivery lumen so as to cause the therapeutic compound to be delivered to the treatment site and a controller configured to control the ultrasound signal generator and the infusion pump.

US Patent:

20210339055, Nov 4, 2021

Filed:

Jul 13, 2021

Appl. No.:

17/374524

Inventors:

- Bothell WA, US
Adrian F. Prokop - Seattle WA, US

Assignee:

EKOS CORPORATION - Bothell WA

International Classification:

A61N 7/02
A61B 17/22
A61M 25/00
A61M 37/00

Abstract:

In one embodiment of the present invention, a system for treating an occlusion within a patient's vasculature with ultrasonic energy comprises a catheter configured to be passed through the patient's vasculature such that a portion of the catheter is positioned at an intravascular treatment site. The system further comprises an ultrasound radiating member, an ultrasound signal generator configured to supply a drive signal to the ultrasound radiating member, an infusion pump configured to pump a therapeutic compound into the fluid delivery lumen so as to cause the therapeutic compound to be delivered to the treatment site and a controller configured to control the ultrasound signal generator and the infusion pump.