Aditya K Unni

US Patent:

8513442, Aug 20, 2013

Filed:

Jun 11, 2007

Appl. No.:

11/811610

Inventors:

Viresh H. Rawal - Chicago IL, US
Yong Huang - Pasadena CA, US
Aditya K. Unni - Chicago IL, US
Avinash N. Thadani - Chicago IL, US

Assignee:

The University of Chicago - Chicago IL

International Classification:

C07D 315/00
C07C 211/00

US Classification:

549416, 549424, 549419, 564462

Abstract:

Methods of performing cycloadditions are described that include (a) combining a first reactant and a second reactant in a hydrogen bonding solvent to form a reaction mixture; and (b) reacting the first reactant and the second reactant to form a cycloadduct. Methods of performing asymmetric catalytic reactions are also described that include (a) combining a first reactant, a second reactant, and a catalytic amount of a chiral hydrogen-bond donor in a solvent to form a reaction mixture; and (b) reacting the first reactant and the second reactant to form an enantiomeric excess of a reaction product. Reaction mixtures corresponding to these methods are also described.

US Patent:

7230125, Jun 12, 2007

Filed:

Jul 28, 2003

Appl. No.:

10/629537

Inventors:

Viresh H. Rawal - Chicago IL, US
Yong Huang - Pasadena CA, US
Aditya K. Unni - Chicago IL, US
Avinash N. Thadani - Chicago IL, US

Assignee:

The University of Chicago - Chicago IL

International Classification:

C07D 315/00

US Classification:

549416, 549330, 549273, 546 16

Abstract:

Methods of performing cycloadditions are described that include (a) combining a first reactant and a second reactant in a hydrogen bonding solvent to form a reaction mixture; and (b) reacting the first reactant and the second reactant to form a cycloadduct. Methods of performing asymmetric catalytic reactions are also described that include (a) combining a first reactant, a second reactant, and a catalytic amount of a chiral hydrogen-bond donor in a solvent to form a reaction mixture; and (b) reacting the first reactant and the second reactant to form an enantiomeric excess of a reaction product. Reaction mixtures corresponding to these methods are also described.

US Patent:

20220273666, Sep 1, 2022

Filed:

Jul 8, 2020

Appl. No.:

17/597471

Inventors:

- San Diego CA, US
Aditya Krishnan Unni - San Diego CA, US
Yosef Shamay - San Diego CA, US
Kevin Duane Bunker - Escondido CA, US
Peter Qinhua Huang - San Diego CA, US

International Classification:

A61K 31/5377
A61K 31/496
A61K 9/51
A61K 47/64

Abstract:

Various albumin nanoparticle Bcl-2 inhibitor formulations are described, along with methods of using them to treat conditions characterized by excessive cellular proliferation, such as cancer and tumors. In various embodiments, such Bcl-2 inhibitor formulations contain albumin and a compound of the following Formula (I), or a pharmaceutically acceptable salt thereof, where the variables in Formula (I) are defined herein.

US Patent:

20230002426, Jan 5, 2023

Filed:

Nov 12, 2020

Appl. No.:

17/756011

Inventors:

- San Diego CA, US
Brant Clayton Boren - San Diego CA, US
Sobhana Babu Boga - San Diego CA, US
Aditya Krishnan Unni - San Diego CA, US
Peter Qinhua Huang - San Diego CA, US
Kevin Duane Bunker - Escondido CA, US
Benjamin Anthony Pratt - Encinitas CA, US

International Classification:

C07F 9/59
C07F 9/572

Abstract:

Disclosed herein are methods for preparing tertiary alcohols from an optionally substituted phenyl ketone or an optionally substituted pyridinyl ketone that includes the use of a chiral ligand and boron trifluoride diethyl etherate. Tertiary alcohols can be used to prepare synthetic versions of natural products and/or pharmaceuticals.

US Patent:

20210139482, May 13, 2021

Filed:

Feb 26, 2019

Appl. No.:

16/971254

Inventors:

- San Diego CA, US
Kevin Duane Bunker - Escondido CA, US
Brant Clayton Boren - San Diego CA, US
Sayee Gajanan Hegde - San Diego CA, US
Hui Liu - San Diego CA, US
Aditya Krishnan Unni - San Diego CA, US
Sunny Abraham - San Diego CA, US
Chad Daniel Hopkins - San Diego CA, US
Sunil Paliwal - Monroe Township NJ, US

International Classification:

C07D 487/04
C07D 491/048

Abstract:

Compounds of Formula (I) are provided herein. Such compounds, as well as pharmaceutically acceptable salts and compositions thereof, are useful for treating diseases or conditions, including conditions characterized by excessive cellular proliferation, such as breast cancer.