Adelya K Leshchiner

US Patent:

7521434, Apr 21, 2009

Filed:

Jun 27, 2006

Appl. No.:

11/475200

Inventors:

Adelya K. Leshchiner - Cresskill NJ, US
Nancy E. Larsen - Highland Mills NY, US
Edward G. Parent - North Bergen NJ, US

Assignee:

Luromed LLC - Tarrytown NY

International Classification:

A61K 31/728
A61K 31/715

US Classification:

514 54, 514 23, 5361231, 536124

Abstract:

The present invention provides for compositions of hyaluronic acid cross-linked with at least one other hydrophobic polymer to form a copolymer gel. The preferred composition is a formulation containing hyaluronic acid or its derivatives and a silicone base polymer with a functional group capable of reacting with the preferred cross-linker. The silicon may also be a group capable of undergoing further polymerization, or a silicone moiety adding to the hydrophobic nature of the gel. The product can be used alone or contain various other substances or covalently bound substances for numerous useful applications including cosmetic, medical, and drug delivery applications. The present invention also provides processes for preparing them.

US Patent:

8247390, Aug 21, 2012

Filed:

Sep 28, 2009

Appl. No.:

12/586716

Inventors:

Adelya K. Leshchiner - Cresskill NJ, US
Nancy E. Larsen - Highland Mills NY, US
Edward G. Parent - North Bergen NJ, US

Assignee:

LuroMed LLC - Orangeburg NY

International Classification:

A01N 43/04
A61K 31/715

US Classification:

514 54, 424 59

Abstract:

Disclosed are hydrophilic polymers such as polysaccharides, including hyaluronic acid of any origin, modified by reaction with epoxy-functional-silicones. Hydrophobic silicon, which contains chemically active groups covalently attach to the backbone of the hydrophilic polymer and gives these new, modified polymers the ability to dissolve hydrophobic compounds including oils, drugs, and vitamins, while maintaining the hydrophilic properties and benefits of the unmodified polymer. With respect to topical applications these polymers substantially increase the stability of formulations and provide for ease of preparation. The properties and advantages of the original polymer are maintained while other properties are augmented, namely the ability to combine with or dissolve hydrophobic and hydrophilic drugs. The products can be used alone or in combination with other substances for various applications including cosmetic, medical, and drug delivery applications. Also disclosed are methods for preparing them.

US Patent:

8524213, Sep 3, 2013

Filed:

Jun 26, 2006

Appl. No.:

11/475850

Inventors:

Adelya K. Leshchiner - Cresskill NJ, US
Paul Konowicz - Arlington MA, US
Valentina Vasilyeva - Pomona NY, US

Assignee:

Genzyme Corporation - Cambridge MA

International Classification:

A61K 31/74
A61K 9/00
A61K 47/48
A61F 13/00

US Classification:

424 7827, 424422, 424 7808, 424400, 525 542

Abstract:

Disclosed are highly resilient and cohesive gels formed by the cross-linking of hyaluronan or hylan, their salts or derivatives thereof, using divinyl sulfone (DVS) as the cross-linking agent. Also disclosed are viscoelastic fluids containing alkylsulfone groups covalently attached to the backbone of the polymer, formed by the mono-functionalization of the cross-linking monomer DVS with hyaluronan and/or hylan. Mechanical properties such as values of hardness and cohesiveness are specified by the rheological properties of the gels. Also disclosed are methods for the preparation of such products. They have use in many applications as injectable and/or implantable devices and as drug delivery systems.

US Patent:

20050142152, Jun 30, 2005

Filed:

Dec 30, 2004

Appl. No.:

11/026388

Inventors:

Adelya Leshchiner - Cresskill NJ, US
Paul Konowicz - Arlington MA, US

International Classification:

C08F002/00
C08G063/48
C08B037/00

US Classification:

424400000, 525054200, 536053000

Abstract:

Disclosed are highly resilient and cohesive gels formed by the cross-linking of hyaluronan or hylan, their salts or derivatives thereof, using divinyl sulfone (DVS) as the cross-linking agent. Also disclosed are viscoelastic fluids containing alkylsulfone groups covalently attached to the backbone of the polymer, formed by the mono-functionalization of the cross-linking monomer DVS with hyaluronan and/or hylan. Mechanical properties such as values of hardness and cohesiveness are specified by the rheological properties of the gels. Also disclosed are methods for the preparation of such products. They have use in many applications as injectable and/or implantable devices and as drug delivery systems.

US Patent:

20100135935, Jun 3, 2010

Filed:

Nov 28, 2008

Appl. No.:

12/315087

Inventors:

Adelya K. Leshchiner - Cresskill NJ, US
Nancy E. Larsen - Highland Mills NY, US
Edward G. Parent - North Bergen NJ, US

International Classification:

A61K 47/30
A61K 47/36
A61K 47/42
A61K 38/18
A61K 8/73
A61K 31/56
A61K 31/573
A61K 38/12
A61K 31/79

US Classification:

424 59, 514777, 5147723, 514773, 514 12, 514179, 514177, 514 9, 424 7802

Abstract:

Disclosed are compositions comprising crosslinked hyaluronic acid gels, preferably vinyl sulfone cross-linked hyaluronic acid known as hylan B gel, for use in topical cosmetic and dermatological formulations. The hylan B gel in these formulations provides prolonged delivery of incorporated substances to the surface of the skin, to provide a hydrated film on the surface of the skin, and to provide a substantive and compatible film on the skin.

US Patent:

47134488, Dec 15, 1987

Filed:

Mar 12, 1985

Appl. No.:

6/710929

Inventors:

Endre A. Balazs - Ft. Lee NJ
Adolf Leshchiner - Fairview NJ
Adelya Leshchiner - Fairview NJ
Philip Band - Brooklyn NY

Assignee:

Biomatrix, Inc. - Ridgefield NJ

International Classification:

C08B 3708
C08F 800
C12P 1904
C12R 146

US Classification:

536 551

Abstract:

Disclosed is hylan, a chemically modified hyaluronic acid preparation characterized by the presence of small amounts (0. 005-0. 05% by weight) of aldehyde cross-linking groups covalently bonded to the hyaluronic acid molecular chains. Also disclosed is a method of obtaining hylan comprising treating hyaluronic acid in situ in animal tissues containing same with a treatment mixture including a reagent (typically an aldehyde) which is reactive towards hyaluronic acid and the proteins contained in the animal tissue.

US Patent:

52466981, Sep 21, 1993

Filed:

Dec 20, 1991

Appl. No.:

7/811139

Inventors:

Edward Leshchiner - Cresskill NJ
Endre A. Balazs - Fort Lee NJ
Nancy E. Larsen - Highland Mills NY
Adelya Leshchiner - Cresskill NJ

Assignee:

Biomatrix, Inc. - Ridgefield NJ

International Classification:

A61K 3174
A61K 3702
A61K 31715

US Classification:

424 7808

Abstract:

Disclosed are biocompatible viscoelastic gel slurries formed from a polymeric gel, preferably a hyaluronan or a derivative thereof such as hylan swollen in an aqueous medium and a fluid phase which is an aqueous solution of a polymer which may also but not necessarily be a hyaluronan or derivative thereof. Also disclosed are methods of making such slurries, controlling their rheological properties and the uses thereof.

US Patent:

50990136, Mar 24, 1992

Filed:

Nov 16, 1990

Appl. No.:

7/616706

Inventors:

Endre A. Balazs - Ft. Lee NJ
Adolf Leshchiner - Fairview NJ
Adelya Leshchiner - Fairview NJ
Nancy Larsen - Southfield NY
Philip Band - Brooklyn NY

Assignee:

Biomatrix, Inc, - Ridgefield NJ

International Classification:

C08B 3708
C08F 800
C12P 1904
C12R 146

US Classification:

536 551

Abstract:

Disclosed is hylan, a chemically modified hyaluronan preparation characterized by the presence of small amounts (0. 0002-0. 05% by weight) of aldehyde cross-linking groups covalently bonded to the hyaluronan molecular chains. Also disclosed is an improved method of obtaining hylan comprising treating hyaluronan in situ in animal tissues containing same with a treatment mixture including an aldehyde which is reactive towards hyaluronic acid and the proteins contained in the animal tissue. Treatment is effected at temperatures below about 16. degree. C. at very high pH, e. g. , 8-14 whereby the overall yield is increased while maintaining the high molecular weight of the hylan.