Theodore A Adams

US Patent:

50396919, Aug 13, 1991

Filed:

May 8, 1990

Appl. No.:

7/520505

Inventors:

Ciro J. Spagnuolo - Monmouth Junction NJ
Carl Kaiser - Millersville MD
Theodore Adams - Perry Hall MD

Assignee:

Marion Merrell Dow Inc. - Kansas City MO

International Classification:

C07D48704
C07D40506
A61K 31415

US Classification:

514393

Abstract:

Furanone compounds and compositions having anticholinergic activity are described. The compounds have the formula: ##STR1## wherein: the dashed line indicates either the 4,5-unsaturated or the 4,5-dihydrofuranone ring; R. sub. 1 and R. sub. 2 may be the same or different and are hydrogen, thienyl, furanyl, or cycloalkyl (C. sub. 3 -C. sub. 6), benzyl, phenyl, substituted phenyl or substituted benzyl wherein the phenyl or benzyl group may be substituted with halogen, trifluoromethyl, lower alkyl, lower alkoxy or hydroxy; R. sub. 3, R. sub. 4 and R. sub. 5 may be the same or different and are hydrogen, lower alkyl, lower alkyl substituted with a halogen, alkoxy, amino or carboxylic acid group, an alkyl or alkylene bridge between R. sub. 4 and R. sub. 5 or R. sub. 3 and the ring N, trifluoromethyl, nitro, a cycloalkyl group containing 3 to 6 carbons, halogen, benzyl, phenyl, substituted phenyl or substituted benzyl, for which the substituents are the same as those set forth for R. sub. 1 and R. sub. 2 substituted benzyl or phenyl. R. sub.