Maria L. Garcia - Edison NJ Robert A. Giacobbe - Lavellette NJ Otto D. Hensens - Red Bank NJ Gregory J. Kaczorowski - Edison NJ Seok H. Lee - Cranford NJ Owen B. McManus - North Plainfield NJ Deborah L. Zink - Manalapan NJ
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
A01K 3135
US Classification:
514451
Abstract:
The present invention relates to novel potassium channel agonists which are useful in activating the calcium activated Maxi-K potassium channel in mammalian neuronal and smooth muscle tissue. The claimed compounds are of the general formula: ##STR1## In addition, a novel microbiological process for producing the claimed compounds is described.
Maria L. Garcia - Edison NJ Robert A. Giacobbe - Lavellette NJ Otto D. Hensens - Red Bank NJ Seok H. Lee - Cranford NJ Owen B. McManus - North Plainfield NJ Deborah L. Zink - Manalapan NJ
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
A61K 3141 A61K 31395 C07D49822
US Classification:
514379
Abstract:
The present invention relates to compounds of the formula: ##STR1## and the pharmaceutically acceptable salts thereof which are useful as potassium channel antagonists, particularly Maxi-K channel antagonists, and thus useful in treating Alzheimer's Disease and other cognitive disorders. This invention is also related to a method of making the compound of formula (I).
Dr. Lee graduated from the Korea Univ Coll of Med, Chong No Ku, Seoul, So Korea in 1961. She works in Pawtucket, RI and specializes in Family Medicine. Dr. Lee is affiliated with Our Lady Of Fatima Hospital.
Tlbs Nye Markeder Aps Denmark Oct 2010 - Oct 2012
Supervisor
Dimb Oct 2010 - Oct 2012
Chief Executive Officer
Hanscomm Oct 2004 - Dec 2008
Chief Executive Officer
Fibertek Co.ltd May 2002 - Sep 2004
Chief Executive Officer
Ls Cable & System Aug 1994 - Nov 1999
Marketing Manager of Fiber Optic Cable and System
Education:
Inha University 1986 - 1988
Masters, Electrical Engineering
Inha University 1982 - 1986
Bachelors, Electrical Engineering
Skills:
Marketing Strategy Marketing Business Development Business Strategy Strategy Strategic Planning Project Management
eference: NeuM: A Neuron-Selective Probe Incorporates into Live Neuronal Membranes via Enhanced Clathrin-Mediated Endocytosis in Primary Neurons by Yoonsik Sung, Lizaveta Gotina, Kyu Hyeon Kim, Jung Yeol Lee, Seulgi Shin, Hira Aziz, Dong Min Kang, Xiao Liu, Na-Kyeong Hong, Hong-Guen Lee, Jun-Seok Lee, Hy
Date: Apr 23, 2024
Category: Health
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