Mirna L Rodriguez

US Patent:

20160022674, Jan 28, 2016

Filed:

Jun 12, 2015

Appl. No.:

14/738279

Inventors:

- South San Francisco CA, US
Andrew L. MacKinnon - San Francisco CA, US
Mirna L. Rodriguez - San Jose CA, US
Dong Zhang - San Jose CA, US
Francesco Parlati - San Francisco CA, US

International Classification:

A61K 31/501
A61N 5/10
A61K 31/436
A61K 31/517
A61K 45/06
A61K 31/502

Abstract:

The invention relates to methods of treating cancer, myeloproliferative diseases, or immunological or neurological diseases with a combination of a glutaminase inhibitor and an anticancer agent such as an enzyme inhibitor (such as a kinase inhibitor), a mitotic inhibitor, a DNA-modifying agent, or a cytidine analog. The invention further relates to methods of treating cancer, myeloproliferative diseases, or immunological or neurological diseases that are resistant to one or more anticancer agents.

US Patent:

20150258082, Sep 17, 2015

Filed:

Mar 13, 2015

Appl. No.:

14/657584

Inventors:

Francesco Parlati - San Francisco CA, US
Mirna L. Rodriguez - San Jose CA, US
Matthew I. Gross - Novato CA, US
Terri L. Davis - Foster City CA, US
Jim Li - San Francisco CA, US
Lijing Chen - Cupertino CA, US
Bindu Goyal - Fremont CA, US
Guy Laidig - Woodside CA, US
Timothy F. Stanton - Daly City CA, US
Eric B. Sjogren - Mountain View CA, US

International Classification:

A61K 31/454
A61K 31/4402
A61K 31/573

Abstract:

The invention relates to methods of treating cancer, myeloproliferative disorders or immunological diseases with a combination of an immunomodulatory agent and a glutaminase inhibitor. The invention further relates to methods of treating cancer, myeloproliferative disorders, or immunological diseases that are resistant to one or more immunomodulatory agents.