Michael Edward Coleman

US Patent:

8309342, Nov 13, 2012

Filed:

Dec 3, 2008

Appl. No.:

12/746334

Inventors:

Ron Stubbers - Houston TX, US
Michael E. Coleman - Houston TX, US

Assignee:

InGeneron, Inc. - Houston TX

International Classification:

C12P 1/00
C12M 1/00

US Classification:

435267, 4352831

Abstract:

A unitary apparatus for isolating cells from adipose tissue including a lipid separation processor with a dispersing head equipped with a plurality of ports and a digestion chamber for dissociation of the constituent cells disposed in adipose tissue. The lipid separating apparatus is useful for the separation of lipids and adipocytes from a mixed cell population. A cell seeding chamber may be attached to the cell isolation apparatus. The components of the apparatus may be packaged in modular kit form.

US Patent:

20030018984, Jan 23, 2003

Filed:

May 18, 2001

Appl. No.:

09/861101

Inventors:

Michael Coleman - The Woodlands TX, US
Robert Schwartz - Houston TX, US
Francesco DeMayo - Houston TX, US

International Classification:

C12P021/00
A61K048/00
C12N015/74

US Classification:

800/004000, 514/044000, 435/320100, 435/069400

Abstract:

This invention relates to gene delivery and expression, including gene therapy, by using vectors which encode stable mRNA and methods of using such vectors. In particular, this invention relates to vectors which establish controlled expression of recombinant IGF-I genes within tissues at certain levels. The vector includes a 5′ flanking region which includes necessary sequences for expression of a nucleic acid cassette, a 3′ flanking region including a 3′ UTR and/or 3′ NCR, and a linker which connects the 5′ flanking region to a nucleic acid sequence. The linker has a position for inserting a nucleic acid cassette. The linker does not contain the coding sequence of a gene that the linker is naturally associated with. The 3′ flanking region is 3′ to the position for inserting the nucleic acid cassette. The expression vectors of the present invention can also be regulated by a regulatory system and/or constructed with a coating.

US Patent:

20030206910, Nov 6, 2003

Filed:

Sep 3, 2002

Appl. No.:

10/234405

Inventors:

Francois Nicol - Menlo Park CA, US
Jijun Wang - Pearland TX, US
Michael Coleman - The Woodlands TX, US
Fiona MacLaughlin - Belfast, GB
Alain Rolland - San Diego CA, US

International Classification:

A61K048/00

US Classification:

424/178100, 514/044000

Abstract:

The invention features selected polymers such as poloxamer 188 (Pluronic F68), poloxamer 237 (Pluronic F87), poloxamer 401 (Pluronic L121), poloxamer 338 (Pluronic F108), Poloxamer 124 (Pluronic L44), Poloxamer 184 (L-64), and poloxamines (Tetronics 904, 908, 1107, and 90R4) that enhance expression from nucleic acids when administered into an organism, in particular to muscle, and further provides selected poloxamer formulations for delivery of nucleic acids to the liver.

US Patent:

20060013883, Jan 19, 2006

Filed:

Sep 1, 2005

Appl. No.:

11/217266

Inventors:

Francois Nicol - Menlo Park CA, US
Jijun Wang - Pearland TX, US
Michael Coleman - The Woodlands TX, US
Fiona MacLaughlin - Belfast, GB
Alain Rolland - San Diego CA, US

International Classification:

A61K 48/00
A61K 9/14

US Classification:

424486000, 514044000

Abstract:

The invention features selected polymers such as poloxamer 188 (Pluronic F68), poloxamer 237 (Pluronic F87), poloxamer 401 (Pluronic L121), poloxamer 338 (Pluronic F108), Poloxamer 124 (Pluronic L44), Poloxamer 184 (L-64), and poloxamines (Tetronics 904, 908, 1107, and 90R4) that enhance expression from nucleic acids when administered into an organism, in particular to muscle, and further provides selected poloxamer formulations for delivery of nucleic acids to the liver.

US Patent:

20100124563, May 20, 2010

Filed:

Nov 17, 2009

Appl. No.:

12/619977

Inventors:

Michael E. Coleman - The Woodlands TX, US
Eckhard U. Alt - Houston TX, US
Ron Stubbers - Houston TX, US

Assignee:

InGeneron, Inc. - Houston TX

International Classification:

A61F 2/00
A61K 35/12
A61P 17/02
A61P 19/00
C12M 1/00

US Classification:

424423, 424 937, 4352831, 4353071

Abstract:

Apparatus and methods are described for generating autologous tissue grafts, the apparatus including a point of care SVF isolation unit that includes a tissue digestion chamber in fluid communication with a lipid separating chamber, whereby SVF cells are isolated without centrifugation; and a cell seeding chamber in fluid communication with the SVF isolation unit, said cell seeding chamber adapted to support a cell scaffold. Methods and materials for cell seeding, including through the provision of micro rough scaffold surfaces, are also provided.

US Patent:

20100310527, Dec 9, 2010

Filed:

Jan 8, 2010

Appl. No.:

12/684263

Inventors:

Eckhard U. Alt - Houston TX, US
Michael E. Coleman - The Woodlands TX, US

Assignee:

BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM - Austin TX
INGENERON, INC. - Houston TX

International Classification:

A61K 35/12
C12N 5/071
A61P 9/00

US Classification:

424 937, 435325, 435395

Abstract:

Methods and compositions are provided for lineage predetermination of cellular transplants including through liposome mediated transfection with aqueous protein extracts from populations of differentiated mammalian cells, or cellular fractions thereof, wherein the differentiated mammalian cells are enriched in one or more of adipocytes, chondrocytes, endothelial cells, hepatocytes, cardiomyocytes, smooth muscle cells, skeletal muscle cells, cardiac pacemaker cells, Schwann cells, pancreatic islet cells, hematopoietic cells, myeloblasts, neurons, and osteoblasts.

US Patent:

20110070281, Mar 24, 2011

Filed:

Apr 23, 2010

Appl. No.:

12/766757

Inventors:

Andrew M. Altman - Madison WI, US
Eckhard U. Alt - Houston TX, US
Michael E. Coleman - Houston TX, US

International Classification:

A61K 35/12
A61F 2/00
A61P 17/02
A61P 19/08
A61P 19/04
A61P 27/02
A61P 9/10
A61P 25/00
A61P 1/00
A61P 19/02

US Classification:

424422, 424 937

Abstract:

Methods are described for generating autologous tissue grafts, including generating grafts at the point of case, which include isolated cell populations that are enriched with stem cells and are mixed with hyaluronic acid and derivatives thereof. The hyaluronic acid localizes the cells to a desired injection site and stimulates collagen production thus enhancing the viability and the longevity of the graft.

US Patent:

20120195863, Aug 2, 2012

Filed:

Dec 16, 2011

Appl. No.:

13/329143

Inventors:

Eckhard U. Alt - Houston TX, US
Michael E. Coleman - Houston TX, US
Ron Stubbers - Houston TX, US

International Classification:

A61K 35/12
C12M 1/40
C12N 5/077

US Classification:

424 937, 435325, 4352831

Abstract:

This document describes methods and an apparatus for recovery of a cell-enriched matrix and cells (e.g., regenerative cells) from a tissue sample. In some embodiments, at least two rounds of acceleration and deceleration are performed.

Address:

15035 Hiddenwood Dr, Houston, TX 77070

VIN:

2B3CA4CD1AH185710

Make:

DODGE

Model:

CHARGER

Year:

2010

Address:

47 S Circlewood Gln, Spring, TX 77381

Phone:

281-362-1568

VIN:

5FNRL38777B039410

Make:

HONDA

Model:

ODYSSEY

Year:

2007