Joshua A Nichols

US Patent:

20080207541, Aug 28, 2008

Filed:

Mar 15, 2005

Appl. No.:

10/592919

Inventors:

Michael T. Migawa - Carlsbad CA, US
Walter F. Lima - San Diego CA, US
Eric E. Swayze - Carlsbad CA, US
Joshua Nichols - Carlsbad CA, US
Hongjiang Wu - Carlsbad CA, US
Thazha P. Prakash - Carlsbad CA, US
Tadeusz Krzysztof Wyrzykiewicz - Wyoming OH, US
Balkrishen Bhat - Carlsbad CA, US
Stanley T. Crooke - Carlsbad CA, US

International Classification:

A61K 31/70
C12N 15/87
A61P 43/00

US Classification:

514 44, 435455

Abstract:

The present invention provides compositions and methods for the optimization of cleavage of RNA species by RNase H. In some embodiments, the invention provides oligonucleotides that possess two or more regions of differing conformation, and at least one transitional nucleobase positioned between the regions that is capable of modulating transfer of the helical conformation characteristic of the region bound to the 3′hydroxy thereof, to the region bound to the 5′ hydroxyl thereof.

US Patent:

20210355493, Nov 18, 2021

Filed:

Oct 4, 2019

Appl. No.:

17/282340

Inventors:

- Carlsbad CA, US
Joshua Nichols - Carlsbad CA, US
Stanley T. Crooke - Carlsbad CA, US

Assignee:

Ionis Pharmaceuticals, Inc. - Carlsbad CA

International Classification:

C12N 15/113

Abstract:

The present disclosure provides oligomeric compounds comprising a modified oligonucleotide that induces no-go decay of a target mRNA. In certain embodiments, the modified oligonucleotide is complementary to a region within the 3′ half of the coding region of the target mRNA.

US Patent:

20150011001, Jan 8, 2015

Filed:

Jun 13, 2014

Appl. No.:

14/304504

Inventors:

- Carlsbad CA, US
Walter F. Lima - San Diego CA, US
Eric E. Swayze - Encinitas CA, US
Joshua Nichols - Carlsbad CA, US
Hongjiang Wu - Carlsbad CA, US
Thazha P. Prakash - Carlsbad CA, US
Tadeusz Krzysztof Wyrzykiewicz - Wyoming OH, US
Balkrishen Bhat - Carlsbad CA, US
Stanley T. Crooke - Carlsbad CA, US

Assignee:

ISIS PHARMACEUTICALS, INC. - Carlsbad CA

International Classification:

C12N 15/85

US Classification:

435375

Abstract:

The present invention provides compositions and methods for the optimization of cleavage of RNA species by RNase H. In some embodiments, the invention provides oligonucleotides that possess two or more regions of differing conformation, and at least one transitional nucleobase positioned between the regions that is capable of modulating transfer of the helical conformation characteristic of the region bound to the 3′ hydroxy thereof, to the region bound to the 5′ hydroxyl thereof.