James H O'Leary

US Patent:

20110097345, Apr 28, 2011

Filed:

Oct 21, 2010

Appl. No.:

12/909697

Inventors:

John LAMBERT - Cambridge MA, US
James J. O'LEARY - Newton MA, US
Joanne Elizabeth Sarah SCHINDLER - Natick MA, US
Steven WEITMAN - Helotes TX, US
Albert QIN - Winchester MA, US

Assignee:

IMMUNOGEN INC. - Waltham MA

International Classification:

A61K 39/395
A61P 35/00
A61P 35/02

US Classification:

4241781

Abstract:

This invention relates to a method of treatment and dosing regimen for treating disease, such as cancer and mammalian tumors, wherein therapy with a cytotoxic drug is suitable, by the administration of an antibody-toxin conjugate, such as a maytansinoid toxin, by infusion at an initial infusion rate of 1 mg/min or lower on a schedule selected from the group consisting of: (1) an amount of at least about 90 mg/mon day 1 and day 8, every three weeks; (2) at least an amount of about 30 mg/mon day 1, day 2 and day 3, every three weeks; (3) at least an amount of about 45 mg/mon day 1, day 8, and day 15, every 4 weeks; and (4) at least an amount of about 45 mg/mon day 1, day 8 and day 15, every 3 weeks.

US Patent:

20110177064, Jul 21, 2011

Filed:

Jan 21, 2011

Appl. No.:

13/011664

Inventors:

Kathleen R. WHITEMAN - Wilmington MA, US
James J. O'Leary - Newton MA, US
Robert John Lutz - Wayland MA, US

Assignee:

ImmunoGen, Inc. - Waltham MA

International Classification:

A61K 39/395
A61P 35/00

US Classification:

4241331

Abstract:

The present invention relates to surprisingly effective anti-cancer drug combinations, pharmaceutical compositions comprising the same, and uses thereof in the treatment of ovarian cancer. In particular, the present invention is based on the discovery that the administration of a CD56 antibody linked to a cytotoxic compound (e.g.,, an immunoconjugate) in combination with at least two chemotherapeutic agents (in particular a taxane compound and a platinum compound), improves the therapeutic index in the treatment of ovarian cancer over and above the additive effects of the anticancer agents used alone. In one embodiment of the invention, combinations of the CD56 antibody, or fragment thereof, linked to a cytotoxic compound plus additional chemotherapeutic agents have a synergistic effect in the ovarian cancer therapeutic index. The present invention also provides methods of modulating the growth of selected cell populations, such as ovarian cancer cells, by administering a therapeutically effective amount of such combinations.

US Patent:

20120269827, Oct 25, 2012

Filed:

Mar 29, 2012

Appl. No.:

13/434419

Inventors:

Kathleen R. WHITEMAN - Wilmington MA, US
James J. O'Leary - Newton MA, US
Robert John Lutz - Wayland MA, US

Assignee:

ImmunoGen, Inc. - Waltham MA

International Classification:

A61K 39/44
A61P 35/00

US Classification:

4241781

Abstract:

The present invention relates to highly effective anti-cancer drug combinations, pharmaceutical compositions comprising the same, and uses thereof in the treatment of ovarian, peritoneal, or fallopian tube cancer. In particular, the present invention is based on the discovery that the administration of a CD56 antibody linked to a cytotoxic compound (e.g., an immunoconjugate) in combination with a chemotherapeutic agent (in particular a gemcitabine compound, a topotecan compound, and a doxorubicin compound), improves the therapeutic index in the treatment of ovarian, peritoneal, or fallopian tube cancer over and above the additive effects of the anticancer agents used alone. In one embodiment of the invention, combinations of the CD56 antibody, or fragment thereof, linked to a cytotoxic compound plus an additional chemotherapeutic agent have a synergistic effect in the ovarian cancer therapeutic index.

US Patent:

53585119, Oct 25, 1994

Filed:

Nov 24, 1992

Appl. No.:

7/981011

Inventors:

Roland F. Gatturna - Walpole MA
James E. Nicholson - Lincoln MA
James O'Leary - Medford MA

Assignee:

Mitek Surgical Products, Inc. - Norwood MA

International Classification:

A61B 1700

US Classification:

606232

Abstract:

A suture anchor for anchoring one end of a conventional suture to bone comprising a coupling member, at least one barb made of a resilient elastic material projecting form said coupling member, and means for attaching one end of a suture to said suture anchor. The coupling member and the at least one barb and adapted to securely anchor one end of the suture in bone when the suture is attached to the attachment means so that the other end of the suture extending outside the bone can be used to attach objects to the bone. A novel application tool is also provided.

US Patent:

57255571, Mar 10, 1998

Filed:

Aug 27, 1996

Appl. No.:

8/703526

Inventors:

Roland F. Gatturna - Walpole MA
James E. Nicholson - Lincoln MA
James O'Leary - Medford MA

Assignee:

Mitek Surgical Products, Inc. - Westwood MA

International Classification:

A61B 1704

US Classification:

606232

Abstract:

A suture anchor for anchoring one end of a conventional suture to bone comprising a coupling member, at least one barb made of a resilient elastic material projecting form said coupling member, and means for attaching one end of a suture to said suture anchor. The coupling member and the at least one barb and adapted to securely anchor one end of the suture in bone when the suture is attached to the attachment means so that the other end of the suture extending outside the bone can be used to attach objects to the bone. A novel application tool is also provided.

US Patent:

62243799, May 1, 2001

Filed:

Oct 2, 1998

Appl. No.:

9/165387

Inventors:

Behrouz Abedian - Lincoln MA
Livia M. Racz - Arlington MA
James P. O'Leary - Medford MA
Philip L. Millstein - Cambridge MA

Assignee:

Trustees of Tufts College - Medford MA

International Classification:

A61C 502

US Classification:

433224

Abstract:

A spinning end of a rotating instrument is used to deform an adhesive material without the adhesive material adhering to the instrument. This process is particularly suited for packing dental composites within oral cavities.

US Patent:

52580156, Nov 2, 1993

Filed:

May 3, 1991

Appl. No.:

7/695536

Inventors:

Lehmann K. Li - Wellesley MA
James P. O'Leary - Medford MA

Assignee:

American Cyanamid Company - Stamford CT

International Classification:

A61B 1700

US Classification:

606232

Abstract:

An improved locking cap for mounting on the smooth flexible filament of a surgical fastener wherein the locking cap is of a thin flat washer-like shape with gripping elements for engaging the filament and locking the cap in position relative to the filament.

US Patent:

51923033, Mar 9, 1993

Filed:

Mar 18, 1992

Appl. No.:

7/853261

Inventors:

Roland F. Gatturna - Walpole MA
James E. Nicholson - Lincoln MA
James O'Leary - Medford MA

Assignee:

Mitek Surgical Products, Inc. - Norwood MA

International Classification:

A61B 1700

US Classification:

606232

Abstract:

A suture anchor for anchoring one end of a conventional suture to bone comprising a coupling member, at least one barb made of a resilient elastic material projecting form said coupling member, and means for attaching one end of a suture to said suture anchor. The coupling member and the at least one barb and adapted to securely anchor one end of the suture in bone when the suture is attached to the attachment means so that the other end of the suture extending outside the bone can be used to attach objects to the bone. A novel application tool is also provided.