Hye Lee

US Patent:

7332329, Feb 19, 2008

Filed:

Sep 21, 2005

Appl. No.:

11/231626

Inventors:

Alastair William Wark - Irvine CA, US
Hye Jin Lee - Irvine CA, US
Robert Marcus Corn - Corona del Mar CA, US
Voula Kodoyianni - Madison WI, US

Assignee:

Wisconsin Alumni Research Foundation - Madison WI

International Classification:

C12M 1/34

US Classification:

4352872, 385 12, 385129, 385130, 422 8205, 422 8211, 435 6, 4352879, 4352887, 435808, 435973, 436164, 436524, 436525, 436805, 436809

Abstract:

A substrate for testing a carrier liquid for biomolecules using SPR or other techniques provides a metallic island surrounded by a hydrophobic layer, the islands being a location for the attachment of probe molecules. The hydrophobic layer may also be a dielectric material providing improved sensitivity in SPR imaging.

US Patent:

7939345, May 10, 2011

Filed:

Jan 16, 2008

Appl. No.:

12/015186

Inventors:

Alastair William Wark - Irvine CA, US
Hye Jin Lee - Irvine CA, US
Robert Marcus Corn - Corona del Mar CA, US
Voula Kodoyianni - Madison WI, US

Assignee:

Wisconsin Alumni Research Foundation - Madison WI

International Classification:

G01N 33/553

US Classification:

436525, 436164, 436172, 436524, 436805

Abstract:

A substrate for testing a carrier liquid for biomolecules using SPR or other techniques provides a metallic island surrounded by a hydrophobic layer, the islands being a location for the attachment of probe molecules. The hydrophobic layer may also be a dielectric material providing improved sensitivity in SPR imaging.

US Patent:

56930151, Dec 2, 1997

Filed:

Jun 6, 1995

Appl. No.:

8/469265

Inventors:

Blair Walker - Long Beach CA
Manouchehr Miraki - Aliso Viejo CA
William Rice - Irvine CA
Brett Trauthen - Newport Beach CA
Hye Lee - Garden Grove CA
Greg Welsh - Newport Beach CA
Henry Nita - Mission Viejo CA
Shawn O'Leary - Newport Beach CA

Assignee:

Advanced Cardiovascular Systems, Inc. - Santa Clara CA

International Classification:

A61M 2900

US Classification:

604 96

Abstract:

A balloon catheter includes a flexible small-diameter guide wire provided with an enlarged-diameter distal end portion, and a flexible elongated tubular shaft with at least one dual-function fluid-conducting lumen adapted to both receive the guide wire extending therethrough, and to communicate pressurized inflation fluid to a distal balloon of the catheter. A distal orifice of the catheter communicates with the balloon and is provided with selective valving means for releasably engaging sealingly with the enlarged distal end portion of the guide wire. Apparatus is disclosed for axially moving the guide wire to effect engagement and disengagement of the enlarged distal end portion with the selective valving means of the catheter shaft. A torquer device is also provided by means of which the guide wire may be rotated relative to the catheter shaft for steering of the guide wire along a vascular pathway. A distal end tapered portion of the catheter shaft provides protection for a joint of the guide wire assembly.