David C Moebius

US Patent:

20220281850, Sep 8, 2022

Filed:

Feb 15, 2022

Appl. No.:

17/672594

Inventors:

- Thousand Oaks CA, US
- San Francisco CA, US
John BUTLER - Somerville MA, US
Aroop CHANDRA - South San Francisco CA, US
Chihyuan CHUANG - Millbrae CA, US
Scott E. COLLIBEE - San Carlos CA, US
Mikkel DEBENEDETTO - Shrewsbury MA, US
Vincent DIMASSA - South San Francisco CA, US
Russell GRACEFFA - Hampton NH, US
Justin MALINOWSKI - Charlestown MA, US
David MOEBIUS - Westwood MA, US
Bradley P. MORGAN - Moraga CA, US
Joshua PAYETTE - Santa Clara CA, US
Antonio ROMERO - San Mateo CA, US
Richard VARGAS - Bedford MA, US
John YEOMAN - Medford MA, US
Hanmo ZHANG - Chestnut Hill MA, US
Alan CHENG - San Francisco CA, US
Felix GONZALEZ LOPEZ DE TURISO - Cambridge MA, US
Michael Garrett JOHNSON - San Francisco CA, US

International Classification:

C07D 403/12
C07D 401/14
C07D 401/12
A61P 9/00
C07D 413/14
C07D 207/16
C07D 209/52
C07D 405/12
C07D 417/14
C07D 401/06
C07D 403/14
C07D 209/02
C07D 413/12

Abstract:

The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.

US Patent:

20200291018, Sep 17, 2020

Filed:

Jul 13, 2018

Appl. No.:

16/630059

Inventors:

- Cambridge MA, US
Goran MALOJCIC - Boston MA, US
William SINKO - Roslindale MA, US
Stephane CIBLAT - Montreal, CA
Clint JAMES - Laval, CA
Huiping Amy GUAN - Acton MA, US
Jason J. MARINEAU - Franklin MA, US
David MOEBIUS - Westwood MA, US

Assignee:

Syros Pharmaceuticals, Inc. - Cambridge MA

International Classification:

C07D 471/04

Abstract:

Described herein are compounds, methods of making such compounds, pharmaceutical compositions, and medicaments comprising such compounds, and methods of using such compounds to treat diseases, such as cancer.

US Patent:

20200223829, Jul 16, 2020

Filed:

Mar 27, 2020

Appl. No.:

16/833321

Inventors:

- Thousand Oaks CA, US
- South San Francisco CA, US
John Butler - Somerville MA, US
Aroop Chandra - South San Francisco CA, US
Chihyuan Chuang - Millbrae CA, US
Scott E. Collibee - San Carlos CA, US
Mikkel V. Debenedetto - Shrewsbury MA, US
Vincent DiMassa - South San Francisco CA, US
Russell Graceffa - Hampton NH, US
Justin Malinowski - Charlestown MA, US
David Moebius - Westwood MA, US
Bradley Paul Morgan - Moraga CA, US
Joshua Payette - Santa Clara CA, US
Antonio Romero - San Mateo CA, US
Richard Vargas - Bedford MA, US
John Yeoman - Medford MA, US
Hanmo Zhang - Chestnut Hill MA, US
Alan Cheng - San Francisco CA, US
Felix Gonzalez Lopez De Turiso - Cambridge MA, US
Michael Garrett Johnson - San Francisco CA, US

International Classification:

C07D 403/12
C07D 401/14
C07D 401/12
A61P 9/00
C07D 413/14
C07D 207/16
C07D 209/52
C07D 405/12
C07D 417/14
C07D 401/06
C07D 403/14
C07D 209/02
C07D 413/12

Abstract:

The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.

US Patent:

20200223830, Jul 16, 2020

Filed:

Mar 27, 2020

Appl. No.:

16/833336

Inventors:

- Thousand Oaks CA, US
- South San Francisco CA, US
John Butler - Somerville MA, US
Aroop Chandra - South San Francisco CA, US
Chihyuan Chuang - Millbrae CA, US
Scott E. Collibee - San Carlos CA, US
Mikkel V. Debenedetto - Shrewsbury MA, US
Vincent DiMassa - South San Francisco CA, US
Russell Graceffa - Hampton NH, US
Justin Malinowski - Charlestown MA, US
David Moebius - Westwood MA, US
Bradley Paul Morgan - Moraga CA, US
Joshua Payette - Santa Clara CA, US
Antonio Romero - San Mateo CA, US
Richard Vargas - Bedford MA, US
John Yeoman - Medford MA, US
Hanmo Zhang - Chestnut Hil MA, US
Alan Cheng - San Francisco CA, US
Felix Gonzalez Lopez De Turiso - Cambridge MA, US
Michael Garrett Johnson - San Francisco CA, US

International Classification:

C07D 403/12
C07D 401/14
C07D 401/12
A61P 9/00
C07D 413/14
C07D 207/16
C07D 209/52
C07D 405/12
C07D 417/14
C07D 401/06
C07D 403/14
C07D 209/02
C07D 413/12

Abstract:

The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.

US Patent:

20200207809, Jul 2, 2020

Filed:

Mar 13, 2020

Appl. No.:

16/818731

Inventors:

- Thousand Oaks CA, US
Henry Johnson - San Bruno CA, US
Simeon Bowers - Oakland CA, US
David C. Moebius - Westwood MA, US

International Classification:

C07K 5/097
C07K 5/072
C07K 5/062
A61K 38/06
C07K 5/078
C07K 5/083
C07K 5/065
C07K 5/06
C07K 5/02
C07D 303/32
C07D 409/12
C07D 405/12

Abstract:

Provided herein are tripeptide epoxy ketone protease inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula (X):and pharmaceutically acceptable salts and compositions including the same. The compounds and compositions provided herein may be used, for example, in the treatment of diseases including inflammation and neurodegenerative disease.

US Patent:

20190300507, Oct 3, 2019

Filed:

Nov 3, 2017

Appl. No.:

16/347970

Inventors:

- Thousand Oaks CA, US
Alan C. CHENG - San Francisco CA, US
Mikkel V. DEBENEDETTO - Waltham MA, US
Paul John DRANSFIELD - Arlington MA, US
James S. HARVEY - Arlington MA, US
Jonathan HOUZE - Cambridge MA, US
Aarif Yusuf KHAKOO - Woodside CA, US
Su-Jen LAI - Cambridge MA, US
Zhihua MA - Lexington MA, US
Vatee PATTAROPONG - Bedford MA, US
Gayathri SWAMINATH - Brisbane CA, US
Charles KREIMAN - Hopkinton MA, US
David C. MOEBIUS - Westwood MA, US
Ankit SHARMA - Quincy MA, US

Assignee:

AMGEN INC. - Thousand Oaks CA

International Classification:

C07D 401/14
C07D 405/14
C07D 417/14
C07D 413/14
A61P 9/04

Abstract:

Compounds of Formula I and Formula II, pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, I or mixtures thereof are agonists of the APJ Receptor and may have use in treating cardiovascular and other conditions. Compounds of Formula I and Formula II have the structures where the definitions of the variables are provided herein.

US Patent:

20190077793, Mar 14, 2019

Filed:

Sep 13, 2018

Appl. No.:

16/129862

Inventors:

- Thousand Oaks CA, US
- South San Francisco CA, US
John Butler - Somerville MA, US
Aroop Chandra - South San Francisco CA, US
Chihyuan Chuang - Millbrae CA, US
Scott E. Collibee - San Carlos CA, US
Mikkel Debenedetto - Waltham MA, US
Vincent DiMassa - South San Francisco CA, US
Russell Graceffa - Hampton NH, US
Justin Malinowski - Charlestown MA, US
David Moebius - Westwood MA, US
Bradley P. Morgan - Moraga CA, US
Joshua Payette - Hollis NH, US
Antonio Romero - San Mateo CA, US
Richard Vargas - Bedford MA, US
John Yeoman - Medford MA, US
Hanmo Zhang - Chestnut Hill MA, US

International Classification:

C07D 403/12
C07D 401/14
C07D 401/12
C07D 405/12
C07D 413/14
C07D 207/16
C07D 209/52
A61P 9/00

Abstract:

The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.

US Patent:

20160368946, Dec 22, 2016

Filed:

Aug 30, 2016

Appl. No.:

15/251688

Inventors:

- Thousand Oaks CA, US
Henry Johnson - San Bruno CA, US
Simeon Bowers - Oakland CA, US
David C. Moebius - Foster City CA, US

International Classification:

C07K 5/097
C07K 5/078
C07K 5/062

Abstract:

Provided herein are tripeptide epoxy ketone protease inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula (X):and pharmaceutically acceptable salts and compositions including the same. The compounds and compositions provided herein may be used, for example, in the treatment of diseases including inflammation and neurodegenerative disease.