Zheng Xin Dong - Holliston MA, US David H. Coy - New Orleans LA, US
Assignee:
Societe de Conseils de Recherches et d'Applications Scientifiques, SAS - Paris The Administrators of the Tulane Educational Fund - New Orleans LA
International Classification:
A61K 38/26 C07K 14/605
US Classification:
514 12, 530324, 530308
Abstract:
The present invention is directed to peptide analogues of glucagon-like peptide-1, the pharmaceutically-acceptable salts thereof, to methods of using such analogues to treat mammals and to pharmaceutical compositions useful therefor comprising said analogues.
Method Of Modulating The Proliferation Of Medullary Thyroid Carcinoma Cells
Ettore Degli Uberti - Ferrara, IT Maria Zatelli - Ferrara, IT Michael Culler - Hopkinton MA, US David Coy - New Orleans LA, US
International Classification:
A61K 38/12 A61P 35/00 C12N 5/02
US Classification:
514009000, 435375000
Abstract:
The present invention is directed to a method of decreasing the rate of proliferation of medullary thyroid carcinoma cells which comprises contacting medullary thyroid carcinoma cells with one or more SSTR2 agonist. A somatostatin receptor antagonist having the formula Cpa-cyclo(D-Cys-4-Pal-D-Trp-Lys-Thr-Cys)-Nal-NHis also disclosed.
The present invention is directed to peptide analogues of glucagon-like peptide-1, the pharmaceutically-acceptable salts thereof, to methods of using such analogues to treat mammals and to pharmaceutical compositions useful therefor comprising said analogues.
Method Of Modulating The Proliferation Of Medullary Thyroid Carcinoma Cells
Ettore Ciro Degli Uberti - Ferrara, IT Maria Chiara Zatelli - Ferrara, IT Michael Dewitt Culler - Hopkinton MA, US David H. Coy - New Orleans LA, US
International Classification:
C12N 5/09 C07K 7/00
US Classification:
435375, 530318
Abstract:
The present invention is directed to a method of decreasing the rate of proliferation of medullary thyroid carcinoma cells which comprises contacting medullary thyroid carcinoma cells with one or more SSTR2 agonist. A preferred selective somatostatin receptor type-2 (SSTR-2) agonist cyclo[Tic-Tyr-D-Trp-Lys-Abu-Phe] is also disclosed.
Name / Title
Company / Classification
Phones & Addresses
David Coy Soc signatory
NORDEN BROTHERS ROOFING & SHEET METAL, LLC
30 Pleasant St, Wakefield, MA 01880 East Weymouth, MA 02189
Dr. Coy graduated from the Northeastern Ohio Universities College of Medicine in 1995. He works in Indio, CA and specializes in Obstetrics & Gynecology. Dr. Coy is affiliated with John F Kennedy Memorial Hospital.