Cheng Z Yu

US Patent:

7586008, Sep 8, 2009

Filed:

Jul 9, 2008

Appl. No.:

12/170314

Inventors:

Chunlin Tao - Los Angeles CA, US
Cheng Zhi Yu - San Diego CA, US
Neil P. Desai - Los Angeles CA, US
Vuong Trieu - Calabasas CA, US

Assignee:

Abraxis Bioscience, Inc. - Los Angeles CA

International Classification:

C07C 49/00
C07C 325/00
C07F 9/02
A61K 31/12
A61K 31/125

US Classification:

568325, 568 20, 568 25, 568333, 568336, 558177, 514438, 514675, 514687, 514690

Abstract:

The invention provides para substituted dialkylphenol derivatives of propofol. The invention further provides pharmaceutical compositions comprising such analogs, methods for preparing such analogs, and methods of using such analogs to induce general anesthesia, sedation, and/or hypnotic or sleep effects in a patient.

US Patent:

7700612, Apr 20, 2010

Filed:

Dec 23, 2004

Appl. No.:

10/583803

Inventors:

Patrick Soon-Shiong - Los Angeles CA, US
Neil P. Desai - Santa Monica CA, US
Chunlin Tao - Beverly Hills CA, US
Cheng Zhi Yu - San Diego CA, US

Assignee:

Abraxis BioScience, LLC - Los Angeles CA

International Classification:

A61K 31/4745
C07D 491/22

US Classification:

514283, 546 48

Abstract:

The present invention is related to 10,20-di-O ester derivatives of camptothecin and pharmaceutical formulations thereof. The compounds and pharmaceutical formulations of the present invention possess increased biological life span and bioavailability and reduced toxicity, while maintaining anti-cancer activity.

US Patent:

8026275, Sep 27, 2011

Filed:

Feb 17, 2006

Appl. No.:

11/816311

Inventors:

Neil P. Desai - Los Angeles CA, US
Chunlin Tao - Los Angeles CA, US
Cheng Zhi Yu - San Diego CA, US
Vuong Trieu - Calabasas CA, US
Patrick Soon-Shiong - Los Angeles CA, US

Assignee:

Abraxis BioScience, LLC - Los Angeles CA

International Classification:

A01N 43/06
A01N 36/00
A61K 31/12
A61K 31/38

US Classification:

514438, 514675, 514687, 514690

Abstract:

The present invention provides novel 2,6-diisopropyl phenol2,6-diisopropyl phenol analogs and sterile, stable pharmaceutical compositions of 2,6-diisopropyl phenol 2,6-diisopropyl phenol and analogs thereof useful as an antioxidant in the treatment of ischemic injury including stroke and other cerebral injury. 2,6-diisopropyl phenol or its analogs are administered in a dosage effective to produce blood levels and brain levels of the drug that can prevent free radical damage associated with ischemic injury.

US Patent:

8395715, Mar 12, 2013

Filed:

Dec 21, 2010

Appl. No.:

12/975284

Inventors:

Cheng Ho Yu - Cupertino CA, US
Ming Xu - Sunnyvale CA, US
Young-Bae Park - San Jose CA, US
Zhibing Ge - Sunnyvale CA, US
Daisuke Nozu - Kita, JP
Cheng Chen - San Jose CA, US
Abbas Jamshidi Roudbari - Sunnyvale CA, US
Shih Chang Chang - San Jose CA, US
Shawn R. Gettemy - San Jose CA, US

Assignee:

Apple Inc. - Cupertino CA

International Classification:

G02F 1/141
G02F 1/133

US Classification:

349 37, 349 33

Abstract:

Display ground plane structures may contain slits. Image pixel electrodes in the display may be arranged in rows and columns. Image pixels in the display may be controlled using gate lines that are associated with the rows and data lines that are associated with the columns. An electric field may be produced by each image pixel electrode that extends through a liquid crystal layer to an associated portion of the ground plane. The slits in the ground plane may have a slit width. Data lines may be located sufficiently below the ground plane and sufficiently out of alignment with the slits to minimize crosstalk from parasitic electric fields. A three-column inversion scheme may be used when driving data line signals into the display, so that pairs of pixels that straddle the slits are each driven with a common polarity. Gate line scanning patterns may be used that enhance display uniformity.

US Patent:

8648845, Feb 11, 2014

Filed:

May 24, 2011

Appl. No.:

13/143187

Inventors:

Shih Chang Chang - San Jose CA, US
Cheng Ho Yu - Cupertino CA, US
Zhibing Ge - Sunnyvale CA, US
Hopil Bae - Sunnyvale CA, US

Assignee:

Apple Inc. - Cupertino CA

International Classification:

G06F 3/038

US Classification:

345211, 345690, 345691

Abstract:

With respect to liquid crystal display inversion schemes, a large change in voltage on a data line can affect the voltages on adjacent data lines due to capacitive coupling between data lines. The resulting change in voltage on these adjacent data lines can give rise to visual artifacts in the data lines' corresponding sub-pixels. Various embodiments of the present disclosure serve to prevent or reduce persisting visual artifacts by offsetting their effects or by distributing their presence among different colored sub-pixels. In some embodiments, this may be accomplished by using different write sequences during the update of a row of pixels.

US Patent:

20070185217, Aug 9, 2007

Filed:

Dec 23, 2004

Appl. No.:

10/584017

Inventors:

Chunlin Tao - Los Angeles CA, US
Cheng Yu - San Diego CA, US
Neil Desai - Santa Monica CA, US
Vuong Trieu - Calabasas CA, US

Assignee:

ABRAXIS BIOSCIENCE, INC. - LOS ANGELES CA

International Classification:

A61K 31/05

US Classification:

514730000, 568017000, 568300000, 568745000

Abstract:

The invention provides para substituted dialkylphenol derivatives of propofol. The invention further provides pharmaceutical compositions comprising such analogs, methods for preparing such analogs, and methods of using such analogs to induce general anesthesia, sedation, and/or hypnotic or sleep effects in a patient.

US Patent:

20090130163, May 21, 2009

Filed:

Feb 21, 2006

Appl. No.:

11/816307

Inventors:

Neil P. Desai - Los Angeles CA, US
Chunlin Tao - Los Angeles CA, US
Cheng Zhi Yu - San Diego CA, US
Qinwei Wang - Arcadia CA, US
Patrick Soon-Shiong - Los Angeles CA, US

Assignee:

Abraxis Bio Scoence, Inc. - Los Angeles CA

International Classification:

A61F 2/04
A61K 31/337
A61K 31/4375
A61K 31/395
A61K 31/09
C07D 305/08
A61K 31/44
A61K 31/436
A61K 9/00

US Classification:

424423, 514449, 424400, 514283, 514291, 514183, 514355, 514719, 549510

Abstract:

The invention provides a medical device comprising a hydrophobic analog of a medicament known to inhibit cell proliferation and migration. The invention also provides a method of treating a narrowing in a body passageway comprising placing an implantable medical device comprising a hydrophobic analog of a medicament known to inhibit cell proliferation and migration. The medicaments can be incorporated within or coated on the device. The invention further provides hydrophobic analogs of medicaments known to inhibit cell proliferation and migration.

US Patent:

20100305148, Dec 2, 2010

Filed:

Apr 13, 2010

Appl. No.:

12/759144

Inventors:

Patrick Soon-Shiong - Los Angeles CA, US
Neil P. Desai - Los Angeles CA, US
Chunlin Tao - Los Angeles CA, US
Cheng Zhi Yu - San Diego CA, US

Assignee:

Abraxis BioScience, LLC - Los Angeles CA

International Classification:

A61K 31/4375
C07D 491/22
A61P 35/02
A61P 35/00

US Classification:

514283, 546 48, 977773, 977906

Abstract:

The present invention is related to 10,20-di-O ester derivatives of camptothecin and pharmaceutical formulations thereof. The compounds and pharmaceutical formulations of the present invention possess increased biological life span and bioavailability and reduced toxicity, while maintaining anti-cancer activity.